Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Small molecule inhibitor agerafenib effectively suppresses neuroblastoma tumor growth in mouse models via inhibiting ERK MAPK signaling.
|
31100410 |
2019 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma.
|
31608140 |
2019 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL1β and TNFα established a feedback loop to upregulate ARG2 expression via p38 and extracellular regulated kinases 1/2 (ERK1/2) signaling in neuroblastoma and neural crest-derived cells.
|
30545920 |
2019 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether, these results define the ERK-ETV5-RET pathway as a critical axis driving neuroblastoma oncogenesis downstream of activated ALK.
|
29321660 |
2018 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Early LC3 lipidation induced by d-limonene does not rely on mTOR inhibition, ERK activation and ROS production and it is associated with reduced clonogenic capacity of SH-SY5Y neuroblastoma cells.
|
29496180 |
2018 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In our previous study, both trametinib (MEK inhibitor) and CH5126766 (RAF/MEK inhibitor) showed in vitro antitumor effects on neuroblastoma cells with ERK phosphorylation (pERK).
|
30266481 |
2018 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Induction of MEK/ERK activity by AZD8055 confers acquired resistance in neuroblastoma.
|
29571732 |
2018 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Silencing the ACAT1 Gene in Human SH-SY5Y Neuroblastoma Cells Inhibits the Expression of Cyclo-Oxygenase 2 (COX2) and Reduces β-Amyloid-Induced Toxicity Due to Activation of Protein Kinase C (PKC) and ERK.
|
30541014 |
2018 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data reveal that cearoin induces autophagy, ERK activation and apoptosis in neuroblastoma SH-SY5Y cells, which is mediated primarily by ROS generation, suggesting its therapeutic application for the treatment of neuroblastomas.
|
28178193 |
2017 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We evaluated the response of neuroblastoma cell lines to MEK-ERK pathway inhibition by trametinib.
|
29184034 |
2017 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, RBM3 is the key mediator of mild hypothermia-related protection against UV in neuroblastoma cells, and the neuroprotective effect might be exerted through interfering with pro-apoptotic signaling pathways p38 and JNK and regulating pro-apoptotic proteins Bax and Bad.
|
28831692 |
2017 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clearance of Damaged Mitochondria Through PINK1 Stabilization by JNK and ERK MAPK Signaling in Chlorpyrifos-Treated Neuroblastoma Cells.
|
26892626 |
2017 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PAG1 knockdown in NB cells promotes proliferation and anchorage-independent colony formation with increased activation of AKT and ERK downstream of c-Src, while PAG1 overexpression significantly rescues these effects.
|
26993602 |
2016 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, EGFR regulates Mcl(-)1 dependence in high-risk NB via ERK-mediated phosphorylation of Bim such that EGFR/ERK inhibition renders Mcl(-)1 dependent tumors now reliant on Bcl(-)2.
|
25756510 |
2015 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A cell-based assay was developed using natively expressed ORL-1 receptors on mouse neuroblastoma cells to measure phosphorylated ERK as a reporter of agonist-induced receptor activation and intracellular signaling.
|
25677767 |
2015 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identified β-estradiol and MAPK/ERK as having functional cross-talk with MYCN and being novel targetable vulnerabilities of MYCN-amplified neuroblastoma.
|
26673823 |
2015 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the amount of phosphorylation of the kinase ERK and neurite outgrowth increased upon Cbl-b depletion in several neuroblastoma cell lines.
|
25921289 |
2015 |
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells.
|
24550142 |
2014 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Conditioned medium from the intermittent hypoxia-exposed neuroblastoma cells was found to enhance osteoclastogenesis, up-regulate the mRNAs of osteoclast marker genes including TRAP, CaSR and cathepsin K and induce the activation of ERK, JNK, and p38 in RAW 264.7 cells.
|
25148040 |
2014 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that IFN-β-induced apoptosis of human SH-SY5Y neuroblastoma cells is associated with a long-lasting up-regulation of p38 MAPK activity, stimulation of MK2 and phosphorylation of the pro-survival protein HSP27.
|
25086905 |
2014 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of ERK1 activity using pharmacologic inhibitors of mitogen-activated ERK kinase (MEK1/2) showed significant synergistic growth inhibitory activity when combined with GSK923295 in neuroblastoma, lung, pancreatic and colon carcinoma cell lines.
|
22948716 |
2013 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-κB and p38 MAPK inhibition.
|
23507189 |
2013 |
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Specifically, inhibition of ROCK1 and MAPK1 reduces phosphorylation levels of the motor protein myosin light chain (MLC) leading to a significant inhibition of the invasive and migratory potential of neuroblastoma cells.
|
22382496 |
2012 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Zinc induces expression of the BH3-only protein PUMA through p53 and ERK pathways in SH-SY5Y neuroblastoma cells.
|
19241161 |
2009 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Upregulation of Fas and FasL in Taiwan cobra phospholipase A2-treated human neuroblastoma SK-N-SH cells through ROS- and Ca2+-mediated p38 MAPK activation.
|
19009558 |
2009 |