MAPK3, mitogen-activated protein kinase 3, 5595

N. diseases: 647; N. variants: 7
Disease: Amyloidosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002726
Disease: Amyloidosis
Amyloidosis 		0.040 Biomarker disease BEFREE Additionally, the Aβ-induced ERK1/2 activation was reversed. 30572643 2018
CUI: C0002726
Disease: Amyloidosis
Amyloidosis 		0.040 Biomarker disease BEFREE URMC-099 inhibited mitogen-activated protein kinase 3/4-mediated activation and attenuated β-amyloidosis. 29729668 2018
CUI: C0002726
Disease: Amyloidosis
Amyloidosis 		0.040 AlteredExpression disease BEFREE In neurons, ERK1/2 and PPARγ signaling pathways were activated by MgT treatment, which in turn suppressed (by >80%) the expression of APH-1α/-1β, which is responsible for the deposition of Aβ and potentially contributes to the memory deficit that occurs in AD. 26293690 2015
CUI: C0002726
Disease: Amyloidosis
Amyloidosis 		0.040 AlteredExpression disease BEFREE Then, Aβ 1-42 is the Aβ precursor protein derivative that up-regulates the expression of β-secretase, and c-jun N-terminal kinase (JNK)/c-Jun and ERK1/2 are involved. 22708832 2012