|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL1β and TNFα established a feedback loop to upregulate ARG2 expression via p38 and extracellular regulated kinases 1/2 (ERK1/2) signaling in neuroblastoma and neural crest-derived cells.
|
30545920 |
2019 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ERK1/2 signaling pathway, which promotes cell survival, was the target of DCF1 in neuroblastoma cells.
|
30365123 |
2019 |
|
Neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Down-regulation of AKT protein levels, AKT phosphorylation, and ERK1/2 phosphorylation were also observed in neuroblastoma cells with perampanel treatment.
|
31262884 |
2019 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
5'-Iodotubercidin treatment and INSM1 inhibition suppressed extracellular signal-regulated kinase 1/2 (ERK1/2) activity and the AKT signaling pathways required for NB cell proliferation.
|
30755485 |
2019 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We then demonstrate that the uptake of NB exosomes by MSCs was associated with a rapid increase in ERK1/2 and AKT activation, and that blocking ERK1/2 but not AKT activation inhibited the IL-6 and IL-8/CXCL8 production by MSCs without affecting exosome uptake.
|
28717423 |
2017 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Arctic Aβ40 blocks the nicotine-induced neuroprotective effect of CHRNA7 by inhibiting the ERK1/2 pathway in human neuroblastoma cells.
|
28890319 |
2017 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In mechanistic studies binding of P-selectin to neuroblastoma cells activated Src and several other pro-survival kinases such as ERK1, AKT, FAK and p38.
|
29156825 |
2017 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pinocembrin Attenuates Mitochondrial Dysfunction in Human Neuroblastoma SH-SY5Y Cells Exposed to Methylglyoxal: Role for the Erk1/2-Nrf2 Signaling Pathway.
|
28000163 |
2017 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data point to a new type of protumorigenic CAF in the tumor microenvironment of neuroblastoma and to STAT3 and ERK1/2 as mediators of their activity.<i></i>.
|
28687621 |
2017 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The calcium-sensing receptor is silenced by genetic and epigenetic mechanisms in unfavorable neuroblastomas and its reactivation induces ERK1/2-dependent apoptosis.
|
23108190 |
2013 |
|
Neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
There was a significant correlation between ERK1/2 phosphorylation status in neuroblastoma cell lines and GSK923295 growth inhibitory activity (r = 0.823, p = 0.0006).
|
22948716 |
2013 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The increase in RAR-beta expression and extracellular-regulated kinase 1/2(ERK1/2) phosphorylation in ATRA-incubated cells suggested that RARs and ERK1/2 were in fact activated by ATRA in SH-SY5Y human neuroblastoma cells.
|
17204142 |
2007 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We show here, that in the human neuroblastoma cell line SK-N-SH, the membrane impermeable conjugated 17beta-estradiol (E2BSA) activates mitogen activated protein kinase kinase (MAPKK or MEK) and induces the phosphorylation and activation of both ERK-1 and ERK-2 (mitogen activated protein kinase or MAPK).
|
9275096 |
1997 |