MAPK3, mitogen-activated protein kinase 3, 5595

N. diseases: 647; N. variants: 7
Disease: Endothelial dysfunction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.060 AlteredExpression phenotype BEFREE The HG-induced vascular endothelial dysfunction was associated with increased phosphorylation (activation) of ERK1/2 and p38 MAPK. 30502342 2019
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.060 Biomarker phenotype BEFREE In addition, VE-Cad-Cre<sup>ERT2+</sup>/Panx1<sup>fl/fl</sup> mice (tamoxifen-inducible deletion of Panx1 in vascular endothelium) treated with tamoxifen were significantly protected from IRI (reduced dysfunction, endothelial permeability, edema, proinflammatory cytokines, and neutrophil infiltration) versus vehicle-treated mice. 29745255 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.060 Biomarker phenotype BEFREE Collectively, treatment with BE remarkably attenuates the pathogenesis of PAH, and the protection of BE may be associated with suppressing Akt/Erk1/2/GSK3[Formula: see text]/[Formula: see text]-catenin/ET-1/ET<sub>A</sub>R signaling and preventing endothelial dysfunction. 29737212 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.060 AlteredExpression phenotype BEFREE AGEs cause endothelial dysfunction by a mechanism associated with decreased eNOS expression and increased oxidative stress in HCAECs through activation of p38 and ERK1/2. 28427390 2017
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.060 Biomarker phenotype BEFREE Role of ERK1/2 activation and nNOS uncoupling on endothelial dysfunction induced by lysophosphatidylcholine. 28235709 2017
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.060 Biomarker phenotype BEFREE Glucose and angiotensin II-derived endothelial extracellular vesicles regulate endothelial dysfunction via ERK1/2 activation. 27975141 2017