MAPK3, mitogen-activated protein kinase 3, 5595

N. diseases: 647; N. variants: 7
Disease: HER2-negative breast cancer ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4733095
Disease: HER2-negative breast cancer
HER2-negative breast cancer 		0.020 Biomarker disease BEFREE Notch-1-PTEN-ERK1/2 signaling axis promotes HER2+ breast cancer cell proliferation and stem cell survival. 29743588 2018
CUI: C4733095
Disease: HER2-negative breast cancer
HER2-negative breast cancer 		0.020 AlteredExpression disease BEFREE We show that miR-21 is up-regulated via the MAPK (ERK1/2) pathway upon stimulation of HER2/neu signaling in breast cancer cells, and overexpression of other ERK1/2 activators such as RASV12 or ID-1 is sufficient to induce miR-21 up-regulation in HER2/neu-negative breast cancer cells. 19419954 2009