MAPK7, mitogen-activated protein kinase 7, 5598

N. diseases: 127; N. variants: 6
Disease: Diabetes Mellitus ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.050 Biomarker group BEFREE These results suggest statin-induced activation of an ERK5-dependent Nrf2 pathway reduces VSMC proliferation and migration induced by AGEs, and that the ERK5-Nrf2 signal module be viewed as a potential therapeutic target of vasculopathy in patients with diabetes and complications of the disease. 28542559 2017
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.050 Biomarker group BEFREE Here, we report the critical role of the p90 ribosomal S6 kinase (p90RSK)/ERK5 complex in EC dysfunction in diabetes mellitus and atherosclerosis. 23243209 2013
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.050 Biomarker group BEFREE ERK5 Regulates glucose-induced increased fibronectin production in the endothelial cells and in the retina in diabetes. 23188731 2012
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.050 Biomarker group BEFREE These findings support the idea that ERK5-sumoylation is a novel therapeutic target for the treatment of diabetes-related cardiovascular diseases. 20079693 2010
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.050 AlteredExpression group BEFREE Furthermore, 1 month of diabetes caused a significant increase in retinal ET-1 mRNA and decrease in ERK5 mRNA expression. 20628425 2010