MAPK7, mitogen-activated protein kinase 7, 5598

N. diseases: 127; N. variants: 6
Disease: Mesothelioma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025500
Disease: Mesothelioma
Mesothelioma 		0.040 Biomarker disease BEFREE It can thus be concluded that ERK5 inhibition attenuates mesothelioma tumor growth and this phenomenon in part is regulated by the inflammasome. 29416614 2018
CUI: C0025500
Disease: Mesothelioma
Mesothelioma 		0.040 AlteredExpression disease BEFREE In addition, the ERK5 inhibitor XMD8-92 reduced the expression of phospho-ERK5 and DCLK1 expression in human mesothelioma cell lines. 28560410 2017
CUI: C0025500
Disease: Mesothelioma
Mesothelioma 		0.040 Biomarker disease BEFREE Extracellular signal-regulated kinase 5 and cyclic AMP response element binding protein are novel pathways inhibited by vandetanib (ZD6474) and doxorubicin in mesotheliomas. 24940987 2014
CUI: C0025500
Disease: Mesothelioma
Mesothelioma 		0.040 AlteredExpression disease BEFREE We first showed that crocidolite asbestos activated ERK5 in LP9 cells and mesothelioma cell lines exhibit constitutive activation of ERK5. 23446998 2013