|
Gastroenteritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We specifically identified p38 and JNK1, which are the downstream molecules of receptor tyrosine kinases (RTKs) required for efficient TGEV replication, as A9 targets through plaque assays, qRT-PCR and Western blotting assays. p38 and JNK1 inhibitors and RNA interference further showed that the inhibitory activity of A9 against TGEV infection was mainly mediated by the p38 mitogen-activated protein kinase (MAPK) signaling pathway.
|
31751591 |
2020 |
|
Sarcoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Our results documented that X-rays could induce ER stress in sarcoma and then autophagy was activated by unfolded protein response (UPR) through the IRE1-JNK-pBcl2-Beclin1 signaling axis.
|
31785812 |
2020 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using IPF mouse models, lung fibroblasts for the experiments were treated with miR-448 mimic, miR-448 inhibitor, si-ABCC3, or SP600125 (inhibitor of JNK) to evaluate the cell proliferation and apoptosis in response to miR-448.
|
31506947 |
2020 |
|
Malignant neoplasm of soft tissue
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Our results documented that X-rays could induce ER stress in sarcoma and then autophagy was activated by unfolded protein response (UPR) through the IRE1-JNK-pBcl2-Beclin1 signaling axis.
|
31785812 |
2020 |
|
Alcoholic Intoxication, Chronic
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Dysregulation of c-Jun N-terminal kinase phosphorylation in alcohol dependence.
|
30321699 |
2019 |
|
Barrett Esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Genes regulated by the TGFB and JNK pathway were overexpressed specifically in EAC and dysplastic BE.
|
30768984 |
2019 |
|
Metabolic Bone Disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
An important osteoclastogenesis-regulating signaling pathway (JNK1-Bcl-2-Beclin1-autophagy activation) was identified, which provides novel potential targets for the clinical therapy of metabolic bone diseases.-Ke, D., Ji, L., Wang, Y., Fu, X., Chen, J., Wang, F., Zhao, D., Xue, Y., Lan, X., Hou, J. JNK1 regulates RANKL-induced osteoclastogenesis <i>via</i> activation of a novel Bcl-2-Beclin1-autophagy pathway.
|
31295022 |
2019 |
|
Candidiasis, Chronic Mucocutaneous
|
0.010 |
Biomarker
|
disease |
BEFREE |
Chronic mucocutaneous candidiasis and connective tissue disorder in humans with impaired JNK1-dependent responses to IL-17A/F and TGF-β.
|
31784499 |
2019 |
|
Malignant neoplasm of thyroid
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our data suggest that Mst1 activation and Yap inhibition coordinate to augment thyroid cancer cell death by controlling the JNK-MIEF1-mitochondria pathway, suggesting that differential regulation of the core Hippo pathway components is potentially a novel therapeutic tool for the treatment of thyroid cancer.
|
31139020 |
2019 |
|
CNS disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Taken together, our data first proved the pro-inflammatory function of ATF2 in microglia, and suggested that the TRAF6-JNK/p38-ATF2 axis might promote microglial inflammatory activation and thus aggravate neuronal injury in brain, which might become a potential therapeutic target for CNS diseases.
|
30763583 |
2019 |
|
Chikungunya Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
A strong polar interaction was predicted between Thr-180 (within the phosphorylation lip) of p38 and Gln-273 of nsP2, whereas, no such polar interaction was predicted for the phosphorylation lip of JNK which indicates the differential roles of p-p38 and p-JNK during CHIKV infection in the host macrophages.
|
31031770 |
2019 |
|
Allergic Conjunctivitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the ANXA1<sub>2-26</sub>-Fpr system in the AC was associated with the activation of ERK and JNK.
|
30419240 |
2019 |
|
Connective Tissue Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Chronic mucocutaneous candidiasis and connective tissue disorder in humans with impaired JNK1-dependent responses to IL-17A/F and TGF-β.
|
31784499 |
2019 |
|
Crohn Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Compared to HC, active CD plasma decreased ZO-1 and OCCLUDIN expression on mRNA and protein levels, and led to an increased JNK phosphorylation.
|
30765731 |
2019 |
|
Dejerine-Sottas Disease (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis of inflammatory signalling pathways indicated robust activation and expression of NF-κB/c-Jun/MAPKs (JNK and p38) in DSS treated animal which was strongly abrogated by BLFE treatment.
|
31620885 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
We examined contributions of inflammatory molecules lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), stress-activated kinases (c-Jun N-terminal kinase [JNK] and p38), arginase, and reactive oxygen species to coronary arteriolar dysfunction in a porcine model of type 1 diabetes.
|
31015037 |
2019 |
|
Disseminated Intravascular Coagulation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, a JNK inhibitor (SP600125) and ERK inhibitor (SCH772984) partially protected mice against PAF-induced death, whereas a p38 MAP-kinase inhibitor (SB203580) provided complete protection against DIC and death.
|
31442556 |
2019 |
|
Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
To achieve this goal, we used JNK-knockout mice (Jnk1<sup>-/-</sup>, Jnk2<sup>-/-</sup>, and Jnk3<sup>-/-</sup>), untreated and treated with intraperitoneal injections of kainic acid (KA), as an experimental model of epilepsy.
|
30685843 |
2019 |
|
Esophageal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Systems Biology Analyses Show Hyperactivation of Transforming Growth Factor-β and JNK Signaling Pathways in Esophageal Cancer.
|
30768984 |
2019 |
|
Fibromyalgia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Effect of transcutaneous electrical acupuncture point stimulation on expression of p-JNK in the dorsal root ganglion in a rat model of myofascial pain syndrome.
|
31219313 |
2019 |
|
Guillain-Barre Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GBS infection increased levels of total and phosphorylated mitogen-activated protein kinase (MAPK) family members such as p38 and JNK and induced nuclear factor kappa B (NF-κB) pathway activation.
|
31548323 |
2019 |
|
Immunologic Deficiency Syndromes
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Tai-expressing cells evade death signals by repressing the immune deficiency (IMD) pathway, which operates in parallel to Toll to control nuclear factor κB (NF-κB) activity and independently regulates JNK activity.
|
31402304 |
2019 |
|
Kidney Calculi
|
0.010 |
Biomarker
|
disease |
BEFREE |
ROS and JNK pathways may contribute to CNP-induced cell injury and kidney stone formation.
|
29511793 |
2019 |
|
Myofascial Pain Syndromes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Effect of transcutaneous electrical acupuncture point stimulation on expression of p-JNK in the dorsal root ganglion in a rat model of myofascial pain syndrome.
|
31219313 |
2019 |
|
Neurofibromatosis 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The DUSP inhibitor, BCI, diminished the survival of NF1-deleted Schwann cells and MPNST cell lines through activation of JNK.
|
30936125 |
2019 |