|
Glioblastoma Multiforme
|
0.400 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.370 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Melanosis coli
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> GNG5, LPAR3, MAPK8, and PSMC6 might be candidate biomarkers associated with apoptosis in MC.
|
30559147 |
2019 |
|
Asthma
|
0.050 |
Biomarker
|
disease |
BEFREE |
<b>Conclusions:</b> IL-33 promoted airway remodeling by interacting with ST2 to activate the JNK/STAT3 signaling pathway in asthma.
|
31112061 |
2020 |
|
Neuralgia
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
<b>Results</b>: PRP significantly alleviated allodynia in burn-induced neuropathic pain 4 weeks after treatment, and PTEN expression in the skin and spinal cord were significantly increased in group D compared with the group C. p-PTEN, p-mTOR, and CCL2 expression in neuron cells; p-p38 and p-NFκB expression in microglia; and p-JNK and p-NFκB activation in spinal astrocytes decreased significantly in the group D compared with the group C. <b>Conclusions</b>: PRP is effective in treating burn-induced neuropathic pain and may be used in clinical practice.
|
29483815 |
2018 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>Manilkara zapota</i> (L.) P. Royen Leaf Water Extract Induces Apoptosis in Human Hepatocellular Carcinoma (HepG2) Cells via ERK1/2/Akt1/JNK1 Signaling Pathways.
|
30519270 |
2018 |
|
Colorectal Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
(-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells.
|
15860507 |
2005 |
|
Malignant neoplasm of colon and/or rectum
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
(-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells.
|
15860507 |
2005 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
3-Decylcatechol induces autophagy-mediated cell death through the IRE1α/JNK/p62 in hepatocellular carcinoma cells.
|
28938597 |
2017 |
|
Hepatitis B
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
Hepatitis B virus X protein (pX) activates p38 MAP kinase and JNK pathways and, in response to weak apoptotic signals, sensitizes hepatocytes to apoptosis.
|
15542843 |
2004 |
|
bone destruction
|
0.020 |
Biomarker
|
disease |
BEFREE |
Bone destruction and osteoclast formation were observed to a similar degree in hTNFtg and JNK1-/-hTNFtg animals.
|
15642137 |
2005 |
|
Reoviridae Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Reovirus infection is associated with selective activation of mitogen activated protein kinase (MAPK) cascades including JNK/SAPK.
|
15802955 |
2005 |
|
HIV-1 infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HIV-1 infection generated more reactive oxygen species (ROS), increased the expression of a larger number of molecules involved in cell signaling such as p47, p38alpha, JNK, c-Yes, total PKC, and decreased the expression of molecules such as p38beta, ERK1/2, and XIAP relative to HIV-2 infection.
|
19841866 |
2010 |
|
FANCONI ANEMIA, COMPLEMENTATION GROUP F
|
0.010 |
Biomarker
|
disease |
BEFREE |
FANCF silencing increased JNK and p38 mediated activation of p53 in MX-treated breast cancer cells, activated the mitochondrial apoptosis pathway.
|
22952942 |
2012 |
|
Microcephaly
|
0.010 |
Biomarker
|
disease |
BEFREE |
Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex.
|
24388750 |
2014 |
|
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
B-cell lymphoma-2 homology 3-interacting domain death agonist (Bid) cleavage by JNK/p38 MAPK linked the extrinsic and mitochondrial pathways of apoptosis.
|
28798154 |
2017 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Colon cancer cell lines (HT-29 and HCT-116) were treated with various concentrations of OP-B (0, 5, 10and 20 μmol/l) and JNK inhibitor SP600125.
|
30372822 |
2018 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Colon cancer cell lines (HT-29 and HCT-116) were treated with various concentrations of OP-B (0, 5, 10and 20 μmol/l) and JNK inhibitor SP600125.
|
30372822 |
2018 |
|
Influenza A
|
0.030 |
Biomarker
|
disease |
BEFREE |
Influenza A Virus NS1 Protein Suppresses JNK1-Dependent Autophagosome Formation Mediated by Rab11a Recycling Endosomes.
|
30619194 |
2018 |
|
Nonalcoholic Steatohepatitis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Non-alcoholic steatohepatitis (NASH) is a chronic metabolic syndrome and the CFLAR-JNK pathway can reverse the process of NASH.
|
31384535 |
2019 |
|
Guillain-Barre Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GBS infection increased levels of total and phosphorylated mitogen-activated protein kinase (MAPK) family members such as p38 and JNK and induced nuclear factor kappa B (NF-κB) pathway activation.
|
31548323 |
2019 |
|
Group B Streptococcal Infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GBS infection increased levels of total and phosphorylated mitogen-activated protein kinase (MAPK) family members such as p38 and JNK and induced nuclear factor kappa B (NF-κB) pathway activation.
|
31548323 |
2019 |
|
Guillain-Barre Syndrome, Familial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GBS infection increased levels of total and phosphorylated mitogen-activated protein kinase (MAPK) family members such as p38 and JNK and induced nuclear factor kappa B (NF-κB) pathway activation.
|
31548323 |
2019 |
|
Candidiasis, Chronic Mucocutaneous
|
0.010 |
Biomarker
|
disease |
BEFREE |
Chronic mucocutaneous candidiasis and connective tissue disorder in humans with impaired JNK1-dependent responses to IL-17A/F and TGF-β.
|
31784499 |
2019 |
|
Hypoglycemia
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Hypoglycemia-induced c-Jun phosphorylation is mediated by c-Jun N-terminal kinase 1 and Lyn kinase in drug-resistant human breast carcinoma MCF-7/ADR cells.
|
9115218 |
1997 |