|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, BEX2 expression protects glioma cells against apoptosis mediated through the JNK pathway and is required for glioma cell proliferation through the NF-κB p65.
|
30779920 |
2019 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, FABP7 overexpression in U87 human glioma cell line revealed higher LD accumulation and higher antioxidant defence enzyme (TRX, TRX reductase 1 [TRXRD1]) expression than mock transfection and protected against apoptosis signalling (p38 MAPK, SAPK/JNK and cleaved caspase 3) activation.
|
30680690 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our research indicated a miR-26b/COX-2/ERK/JNK axis in regulating the motility of glioma in vitro and in vivo, providing a new sight for the treatment of glioma.
|
28800785 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these findings demonstrated that highly expressed MKK7 contributes to JNK/c-Jun signaling-mediated glioma formation.
|
30963560 |
2019 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
High expression of mitogen-activated and stress-activated protein kinase 1 indicates poor prognosis in patients with glioma.
|
30020192 |
2018 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We show here that glioma stem cells (GSCs) express low levels of MKP1, a dual-specificity phosphatase, which acts as a negative inhibitor of JNK, ERK1/2, and p38 MAPK, while induction of high levels of MKP1 expression are associated with differentiation of GSC.
|
29284798 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we used glioma cell lines and H<sub>2</sub>O<sub>2</sub> to investigate the role of JNK in glioma cell parthanatos induced by oxidative stress.
|
27181592 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, CTGF silencing and pharmacological inhibition of JNK also inhibited glioma cell migration.
|
27291091 |
2016 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, JNK/MAPK in glioma cells was examined at mRNA and protein levels.
|
26439036 |
2015 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
uPAR and cathepsin B-mediated compartmentalization of JNK regulates the migration of glioma-initiating cells.
|
24699410 |
2014 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly, blockade of JNK signaling with SP600125 or small interfering RNAs targeting JNK1 or JNK2 significantly reduced the CD133(+)/Nestin(+) population and suppressed sphere formation, colony formation in soft agar, and expression of stem cell markers in sphere-cultured glioma cells.
|
22249269 |
2012 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous study indicated that PS-341 induces cell death via JNK pathway in vitro in glioma.
|
21732139 |
2012 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Suppression of MMP-2 attenuates TNF-α induced NF-κB activation and leads to JNK mediated cell death in glioma.
|
21573233 |
2011 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings indicate that scriptaid (i) induces apoptosis and reduces glioma cell proliferation by elevating JNK activation and (ii) also decreases telomerase activity in a JNK-independent manner.
|
19583803 |
2010 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
GST-MDA-7 killed glioma cells with diverse genetic characteristics that were dependent on activation of JNK1-3 with subsequent activation of BAX and the induction of mitochondrial dysfunction.
|
18299661 |
2008 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Glial cell-derived neurotrophic factor (GDNF) promotes low-grade Hs683 glioma cell migration through JNK, ERK-1/2 and p38 MAPK signaling pathways.
|
16814421 |
2006 |