MAPK8, mitogen-activated protein kinase 8, 5599

N. diseases: 520; N. variants: 4
Disease: Liver neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.030 Biomarker group BEFREE Resistance to paclitaxel in hepatoma cells is related to static JNK activation and prohibition into entry of mitosis. 22323130 2012
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.030 Biomarker group BEFREE Taken together, we found that ROS regulate hepatoma cell growth via specific signaling pathways (cross-talk between PI3-K/PKB and JNK pathway) which may provide a novel clue to elucidate the mechanism of hepatoma carcinogenesis. 12361705 2002
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.030 AlteredExpression group BEFREE Treatment of human hepatoma (HepG2) and murine hepatoma (Hepa1c1c7) cells with tert-butylhydroquinone (tBHQ) or sulforaphane (SUL), two potent phase II enzyme inducers, stimulated the activity of extracellular signal-regulated protein kinase 2 (ERK2) but not c-Jun N-terminal kinase 1. tBHQ and SUL also activated MAPK kinase. 10488090 1999