Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results showed that, compared to the OA group, the OA + treadmill and OA + wheel groups had lower levels of IL-1β, IL-6 and TNF-α, and similar levels of p-P65, p-JNK, and P-IκBα.
|
31836142 |
2020 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It was found that LUT effectively inhibited proliferation of OA cartilage cells, down-regulated the expressions of JNK and p38MAPK in cartilage cells of OA, and downregulated NO, TNF-α and IL-6.
|
31472053 |
2019 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Trans-Cinnamaldehyde Inhibits IL-1<i>β</i>-Stimulated Inflammation in Chondrocytes by Suppressing NF-<i>κ</i>B and p38-JNK Pathways and Exerts Chondrocyte Protective Effects in a Rat Model of Osteoarthritis.
|
31205941 |
2019 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
OA-treated DU145 cells were arrested in G2 because of the activation of p-AKT, p-JNK, p21 and p27, and the decrease in p-ERK, cyclin B1 and CDK2 expression; OA-treated MCF-7 cells were arrested in G1 owing to the activation of p-JNK, p-ERK, p21, and p27, and the decrease in p-AKT, cyclin D1, CDK4, cyclin E, and CDK2; and OA-treated U87 cells also exhibited G1 phase arrest caused by the increase in p-ERK, p-JNK, p-AKT, p21, and p27, and the decrease in cyclin D1, CDK4, cyclin E and CDK2.
|
29899865 |
2018 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The positive rates of p-p38, p-JNK and p-ERK in OA cartilage were higher than those in normal cartilage.
|
27907835 |
2017 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study to determine the roles of a potential therapeutic targets miRNA-146a, miRNA-155 and JNK expression levels in OA patients.
|
28647559 |
2017 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To reveal the mechanism and the effect of JNK and p38 MAPKs on matrix metalloproteinase 3 (MMP3) and autophagy in OA, the study established OA model in rabbits, used the measurement of the Osteoarthritis Research Society International scoring system to evaluate OA model, and conducted general observation, histological observation, and Western blotting of JNK, phosphorylate-JNK (P-JNK), p38, phosphorylate-p38 (P-p38), MMP3, and light-chain 3 (LC3)-II/LC3-I to explore the variation of JNK, p38 MAPKs, and autophagy at the early stage of OA.
|
26873249 |
2016 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis.
|
26751999 |
2016 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The basal phosphorylation of mitogen-activated protein kinases (MAPKs) (ERK, JNK, and p38) in OA hMSCs was significantly higher than in normal.
|
25091567 |
2015 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
c-Jun N-terminal kinase - c-Jun pathway transactivates Bim to promote osteoarthritis.
|
24502636 |
2014 |