DisGeNET - a database of gene-disease associations

MAP2K5, mitogen-activated protein kinase kinase 5, 5607

N. diseases: 70; N. variants: 22

Disease: Colon Carcinoma ×

Source: ALL

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Disease

Score _gda

Association Type

Type

Original DB

Sentence supporting the association

PMID

PMID Year

CUI:	C0699790
Disease:	Colon Carcinoma

Colon Carcinoma

0.020

Biomarker

disease

BEFREE

Here, we evaluated the impact of the MEK5/ERK5 cascade in colon cancer cell sensitivity to 5-fluorouracil (5-FU).

27144434

2016

CUI:	C0699790
Disease:	Colon Carcinoma

Colon Carcinoma

0.020

Biomarker

disease

BEFREE

To evaluate the role of MEK5/ERK5 signalling in colon cancer, we developed a stable cell line model with differential MEK5/ERK5 activation.

25855966

2015