|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Comparing ISH with immunohistology (IH) we found a correlation between signals and hormone content in 100% of adenomas for GH, in 60% for Prolactin and in 10% for Gonadotropins.
|
1923947 |
1991 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The percentages of PRL mRNA-containing cells in the four different adenomas amounted to less than 1, 5, 2 and 18.
|
2004472 |
1991 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
CTD_human |
[Morphological changes in prolactinoma induced by bromocriptine treatment].
|
2274009 |
1991 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Thus, the study of PRL gene expression and immunohistochemistry in GH-secreting adenomas is valuable to understanding the pathophysiology of pituitary tumors.
|
2338572 |
1990 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Expression of the SRIH gene was investigated in six human normal anterior pituitaries, six GH-, three PRL-, three mixed GH/PRL-secreting and four nonsecreting adenomas.
|
2571081 |
1989 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Two additional pregnant women, one with a bromocriptine-treated PRL-secreting adenoma (subject C), and a normal woman (subject D) were studied.
|
2715295 |
1989 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In three adenomas (19%) PRL mRNA was detected and in one case (6%) ACTH mRNA was detected.
|
2846798 |
1988 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In the current study we report the cloning, amplification in bacteria, and sequence analysis of DNA complementary to Prl mRNA isolated from human pituitary Prl-secreting adenomas.
|
6260780 |
1981 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Five ACTH producing adenomas, 11 GH producing adenomas, one PRL producing adenoma and five non-functioning adenomas were obtained at surgery.
|
7923822 |
1994 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Both are negatively coupled to adenylyl cyclase and inhibit prolactin secretion, but, in addition, the shortest one (D2S) is more efficiently coupled to phospholipase C. Consequently, we also investigated whether expression of a particular D2 receptor isoform was preferentially affected in resistant adenomas.
|
7969790 |
1994 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Searching for differences in gene expression between different types of human pituitary adenomas, we evaluated the concentration of mRNA from hormonal genes (prolactin and growth hormone) and oncogenes (c-myc and c-fos) in 12 growth hormone-secreting 7 prolactin-secreting and 11 nonsecreting adenomas.
|
8098847 |
1993 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Taken together, the data confirm that Pit-1/GHF-1 expression is restricted to GH-, prolactin- and TSH-expressing cells, and the increased expression in adenomas is compatible with a role of Pit-1/GHF-1 in cell proliferation.
|
8297469 |
1993 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
By RT-PCR, ER mRNA was found in the nontumorous pituitary and in pituitary adenomas expressing only PRL, in those producing GH and PRL, and in adenomas expressing the gonadotropic hormones.
|
8530610 |
1995 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A comparative RT-PCR approach revealed signals for both V3 receptor and CHR receptor mRNAs in 17 of 18 ACTH-secreting pituitary adenomas, and 6 of 6 normal pituitaries; in six growth hormone- or prolactin-secreting adenomas, a very faint V3 receptor signal was observed in three cases, and CRH receptor signal was undetected in all.
|
8636444 |
1996 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Our recent studies found significant amounts of immunoreactive pancreastatin in all pituitary adenomas except prolactin adenomas.
|
8669489 |
1996 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Pit-1 mRNA was detected in 12 (80%) of 15 prolactin-producing adenomas.
|
8733768 |
1996 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Pit-1 mRNA expression was detected in 11 (85%) of 13 PRL-secreting adenomas.
|
8834538 |
1996 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
These adenomas included 13 clinically non-functioning adenomas, 1 GH/PRL-producing adenoma, 6 GH-producing adenomas, 2 PRL-producing adenomas and 1 ACTH-producing adenoma.
|
8881451 |
1996 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Therefore, the presence of unknown transcriptional factor other than Pit-1, common to GH, PRL, and ACTH, may be speculated to be expressed in this adenoma.
|
8890999 |
1996 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Although there were no GH, PRL or TSH-beta transcripts in Pit-1 mRNA-negative ACTH cell and non-functioning adenomas, PRL mRNA was detected in all Pit-1 mRNA-positive ACTH cell adenomas and GH, PRL and/or TSH-beta mRNA were found in four of seven Pit-1 mRNA-positive non-functioning adenomas.
|
8949563 |
1996 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These results indicate that in the normal pituitary, PRL and LH cells have the highest level of PRL-R mRNA, whereas PRL adenomas have significantly higher levels of PRL-R mRNA than other types of adenomas, and bromocriptine treatment decreases the levels of PRL-R mRNA in PRL adenomas.
|
9062514 |
1997 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Adrenocorticotrophic hormone-secreting and prolactin-secreting adenomas did not express GHRH-R message.
|
9176381 |
1997 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
These included 5 gonadotroph adenomas, 6 null cell adenomas, 1 of 2 GH-producing tumors, and 1 of 2 ACTH-producing adenomas, but not in the 2 PRL-producing adenomas examined.
|
9177416 |
1997 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Four tumors were shown to have a hypotriploid chromosomal constitution, two of which also presented structural clonal rearrangements: an isochromosome 1q,i(1)(q10) and a der(1)t(1;3)(p22;q21) were observed in two PRL-secreting adenomas, one of which also had a telomeric association involving the short arms of chromosomes 14 and 19.
|
9332478 |
1997 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
We also immunostained urocortin in 52 cases of human anterior pituitary adenomas, including GH-producing adenomas (n = 14), ACTH-producing adenomas (n = 13), PRL-producing adenomas (n = 11), and nonfunctioning hormonally inactive adenomas (n = 14).
|
9360550 |
1997 |