|
Hyperprolactinemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hyperprolactinemia is an inevitable consequence of treatment with antipsychotic agents to some extent because prolactin response to antipsychotics is related to dopamine blockade.
|
18579277 |
2008 |
|
Hyperprolactinemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Hyperprolactinemia in acute myeloid leukemia and indication of ectopic expression of human prolactin in blast cells of a patient of subtype M4.
|
1968111 |
1990 |
|
Hyperprolactinemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Hyperprolactinemia has been found in patients with systemic lupus erythematosus (SLE), and new evidence has confirmed a significant correlation between serum PRL levels and disease activity.
|
28130617 |
2017 |
|
Hyperprolactinemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Hyperprolactinemia was suspected because of adrenal deficiency that was directly or indirectly associated with increased prolactin levels.
|
30958070 |
2019 |
|
Hyperprolactinemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Hyperprolactinemia was found to be present in Case 2, whereas Case 1 (a 49-year-old woman) had "normal" serum prolactin levels for premenopausal and prolactin levels slightly above the maximum levels for postmenopausal women.
|
31417404 |
2019 |
|
Hyperprolactinemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Prolactin gene polymorphism (-1149 G/T) is associated with hyperprolactinemia in patients with schizophrenia treated with antipsychotics.
|
27776952 |
2017 |
|
Hyperprolactinemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Prolactin takes calcium from the skeletal system following increased Prlr gene expression in the vertebrae to maintain calcium homeostasis, which increases the harmful effect on bone metabolism compared to that of physiological hyperprolactinaemia.
|
30143940 |
2018 |
|
Hyperprolactinemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
PRL values >250 ng/mL are highly suggestive of prolactinomas and virtually exclude nonfunctioning pituitary adenomas (NFPAs) and other sellar masses as the etiology of hyperprolactinemia.
|
30889571 |
2019 |
|
Hyperprolactinemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
A total of 95% of the 20 patients with hyperprolactinemia had progressive disease (PD), according to CT results, whereas only 2 patients (33%) out of 6 with stable PRL levels had PD (p = 0.004).
|
28407622 |
2017 |
|
Hyperprolactinemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Abnormalities in thyroid function and hyperprolactinemia are well-known causes of infertility, but whether thyrotropin (TSH) and prolactin levels within the normal range are associated with UI is unknown.
|
29272395 |
2018 |
|
Hyperprolactinemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adjunctive metformin appears to be effective and safe for reducing antipsychotic-induced hyperprolactinemia and prolactin-related symptoms in schizophrenia patients.
|
28372526 |
2017 |
|
Hyperprolactinemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adverse events potentially related to hyperprolactinemia were more common in participants with elevated prolactin concentration and in girls (45%) compared with boys (10%).
|
19339912 |
2009 |
|
Hyperprolactinemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Although experimental studies showed that PRL has both beneficial and adverse effects on type 2 diabetes mellitus, clinical findings in subjects with hyperprolactinemia indicate adverse effects on glucose metabolism.
|
28384295 |
2017 |
|
Hyperprolactinemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Although there were significant differences in the prevalence of hyperprolactinemia and metabolic syndrome according to the antipsychotic received, multivariant regression analysis did not show a correlation between sexual dysfunction and prolactin, sexual hormones, type of antipsychotic received, psychotic psychopathology or metabolic syndrome.
|
30552811 |
2018 |
|
Hyperprolactinemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Altogether, 11 studies (n=1034, schizophrenia-spectrum=475) for Taq1A polymorphism, and 4 studies (n=451, schizophrenia-spectrum=274) for -141C Ins/Del polymorphism, each reporting on PRL levels but not on the proportion of patients with hyperprolactinemia, were meta-analyzed.
|
27333159 |
2016 |
|
Hyperprolactinemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Antipsychotics are the most common pharmacological agents which cause hyperprolactinemia The aim of this review is to describe PRL physiology, PRL biological effects and pathway to the diagnosis, causes, consequences of HPRL focusing on the antipsychotic effects on the PRL.
|
28440197 |
2017 |
|
Hyperprolactinemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Big big PRL or macroprolactin is a PRL variant with reduced bioactivity towards its homologous receptor, and this altered bioactivity may contribute to the lower disease activity and absence of symptoms related to HPRL in SLE patients.
|
17516622 |
2007 |
|
Hyperprolactinemia
|
0.600 |
Biomarker
|
disease |
CTD_human |
Development of anti-PRL (prolactin) autoantibodies by homologous PRL in rats: a model for macroprolactinemia.
|
17303669 |
2007 |
|
Hyperprolactinemia
|
0.600 |
Biomarker
|
disease |
RGD |
Development of anti-PRL (prolactin) autoantibodies by homologous PRL in rats: a model for macroprolactinemia.
|
17303669 |
2007 |
|
Hyperprolactinemia
|
0.600 |
Biomarker
|
disease |
CTD_human |
Differences in the opioid control of luteinizing hormone secretion between pathological and iatrogenic hyperprolactinemic states.
|
2880862 |
1987 |
|
Hyperprolactinemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Dysregulation of the signaling pathways that govern lactotrope biology contributes to tumorigenesis of prolactin (PRL)-secreting adenomas, or prolactinomas, leading to a state of pathological hyperprolactinemia.
|
25472533 |
2015 |
|
Hyperprolactinemia
|
0.600 |
Biomarker
|
disease |
CTD_human |
Effect of chronic hyperprolactinemia induced by sulpiride on plasma dehydroepiandrosterone (DHA) in normal men.
|
2948424 |
1987 |
|
Hyperprolactinemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Elevated PRL caused by systemic hyperprolactinemia may contribute to the development of PA in those cases in which the two entities coexist.
|
26176803 |
2015 |
|
Hyperprolactinemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Elevated prolactin levels (hyperprolactinemia) are a frequent adverse effect of antipsychotic medications, especially in young populations.
|
28660406 |
2017 |
|
Hyperprolactinemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Fifteen women with hyperprolactinemia and two fertile controls with normal prolactin levels were studied.
|
1426375 |
1992 |