Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Premenopausal women with overt hypothyroidism (thyroid-stimulating hormone [TSH] > 15 IU/L) were tested in the early follicular phase of their natural menstrual cycles or after a progesterone challenge for gonadotropins, estradiol (E<sub>2</sub>), and prolactin (PRL).
|
31259157 |
2019 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hypothyroidism resulted in irregularity of oestrus cycle accompanied with decrease in luteinizing hormone (LH), follicular stimulating hormone (FSH) and estradiol (E2), while prolactin (PRL), progesterone (P) and testosterone (T) hormone were significantly elevated.
|
30403603 |
2018 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
LHX3 mutations are associated with growth hormone, prolactin, gonadotropin, and TSH deficiency; abnormal pituitary morphology; and may be accompanied with limited neck rotation and sensorineural hearing loss.
|
21249393 |
2011 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
POU1F1 (Pit-1; Gene ID 5449) is an anterior pituitary transcriptional factor, and POU1F1 mutation is known to cause anterior pituitary hypoplasia, growth hormone and prolactin deficiency and various degree of hypothyroidism.
|
21316014 |
2011 |
Hypothyroidism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations within POU1F1 are associated with GH, TSH and PRL deficiencies, with the TSH deficiency being highly variable.
|
18174732 |
2007 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most of the affected individuals manifest GH, prolactin, and TSH deficiency.
|
15928241 |
2005 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
The genetic abnormalities include mutations within: (1) Hesx1 (IGHD, SOD or CPHD); (2) Lhx3 (CPHD with preservation of cortisol secretion and a short stiff neck); (3) Lhx4 (GH, TSH and ACTH deficiency with cerebellar hypoplasia); (4) Prop1 (variable CPHD often associated with pituitary masses); (5) POU1F1 (GH, prolactin and TSH deficiency); (6) GHRHR (IGHD) and (7) GH1 (IGHD).
|
12914740 |
2003 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pit-1 gene mutations result in complete growth hormone (GH) and PRL deficiencies and variable degrees of TSH deficiency, producing the clinical syndrome of combined pituitary hormone deficiency (CPHD).
|
9588494 |
1998 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report a child whose hypothyroidism was recognized clinically at age 6 weeks, and subsequently found to have GH and Prl as well as TSH deficiency.
|
9485179 |
1998 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
All had complete GH deficiency and complete or partial Prl and TSH deficiency.
|
9632165 |
1998 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
These patients present extreme short stature, GH, PRL and TSH deficiency but intact ACTH, LH and FSH secretion.The pituitary is usually hypoplastic.
|
9699131 |
1998 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
These patients present extreme short stature, GH, PRL and TSH deficiency but intact ACTH, LH and FSH secretion.The pituitary is usually hypoplastic.
|
9438923 |
1997 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies of kindreds with GH, Prl and TSH deficiency have disclosed a variety of mutations in the Pit-1 gene.
|
8300051 |
1993 |
Hypothyroidism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Four out of 10 children in two unrelated families presented with a total pituitary growth hormone (GH) and prolactin deficiency and a partial thyrotropin (TSH) deficiency.The GH gene was intact in family I.
|
2634610 |
1989 |