|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Based on review articles and reports in reputable peer-reviewed journals and government websites, this paper summarized psychosocial factors (e.g., alexithymia, depression, anxiety, negative emotions, and perceived stress) and sex hormones (e.g., estrogens, progesterone, androgens, and prolactin) involved in SLE.
|
31275761 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Prolactin activates IRF1 and leads to altered balance of histone acetylation: Implications for systemic lupus erythematosus.
|
31104557 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, serum levels of estradiol and prolactin were significantly higher in SLE patients compared to controls (p<0.001).
|
30537797 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
PRL -1149 TT genotype is associated with susceptibility to SLE in a Mexican-Mestizo population, and high PRL serum levels are associated with anti-RNP antibodies and renal activity.
|
30154884 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the domestic dog (Canis lupus familiaris) serum PRL increases in pregnant bitches shortly after RLN appears in the circulation, and a possible functional relationship between the RLN and the PRL systems in regulating progesterone secretion has been implied.
|
29364921 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Methods This cross-sectional study was conducted in consecutive female SLE patients seen in our rheumatology department from January 2012 to July 2015.Prolactin was measured in ng/ml.
|
27852933 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Prolactin (PRL) is an immunomodulatory hormone that may promote LP, as has been documented in other autoimmune disorders, such as systemic lupus erythematosus, rheumatoid arthritis, and psoriasis.
|
28367894 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Meta-analysis revealed that, compared with the control group, the SLE group had significantly higher plasma/serum PRL levels (P < 0.001), with the SMD of 1.26 and 95%CI (0.70，1.82).
|
27666289 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Conclusions Our meta-analysis demonstrated that circulating prolactin levels are higher in patients with SLE, and that a significantly positive correlation exists between prolactin levels and SLE activity.
|
28420051 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
PRL participates in activation of SLE during pregnancy and in pathogenesis of lupus nephritis, neuropsychiatric, serosal, hematologic, articular, and cutaneous involvement.
|
28130617 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of associations between functional prolactin -1149 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus.
|
25724680 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This preliminary study examined the relevance of a -1149G/T functional single-nucleotide polymorphism (SNP) (rs1341239) in the promoter of the extrapituitary prolactin gene in a cohort of African American and European American women with lupus.
|
26583155 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data demonstrate that the prolactin promoter polymorphism -1149 G/T does not significantly contribute to SLE disease susceptibility but does predispose carriers to other immunological changes.
|
21500962 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased prolactin levels have been described in autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, and systemic sclerosis among others.
|
19911311 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
HLA class II, MICA and PRL gene polymorphisms: the common contribution to the systemic lupus erythematosus development in Czech population.
|
20352225 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Further research is required to elucidate molecular mechanisms involved in immune effects of prolactin and to develop novel targeted treatments for SLE patients with prolactin-responsive disease.
|
19937157 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Big big PRL or macroprolactin is a PRL variant with reduced bioactivity towards its homologous receptor, and this altered bioactivity may contribute to the lower disease activity and absence of symptoms related to HPRL in SLE patients.
|
17516622 |
2007 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Sex and systemic lupus erythematosus: the role of the sex hormones estrogen and prolactin on the regulation of autoreactive B cells.
|
16896282 |
2006 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
CTD_human |
After metoclopramide, secretion and production of PRL increased only in PBMNC from control women and not in those from SLE patients.
|
14870917 |
2004 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover a panel of HLA typed SLE and control individuals were individually genotyped for the PRL G-1149T polymorphism previously described to be associated with SLE.
|
12559630 |
2003 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
The exact contribution of PRL to immune responses in normal subjects and in SLE patients is not known.
|
11721698 |
2001 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Characterization of a prolactin gene polymorphism and its associations with systemic lupus erythematosus.
|
11665977 |
2001 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
There is exciting new evidence that HPRL in SLE may be explained by stimulation of pituitary PRL secretion by cytokines.
|
11721702 |
2001 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
This indicates a possible mechanism for the association of prolactin with SLE.
|
11721693 |
2001 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
This indicates a possible mechanism for the association of prolactin with SLE.
|
11721693 |
2001 |