|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Beta-cell function during lactation relates to breastfeeding and circulating prolactin concentrations independently of obesity.
|
30583966 |
2019 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Male and female ob/ob animals (a mouse model of obesity and insulin resistance) were treated with Bromo and/or Prl.
|
30462197 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
PRL excess has been found to worsen glucose profile because it reduces glucose tolerance and induces insulin resistance either in obese and non-obese patients.
|
31191454 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Adrenergic hormones induce extrapituitary prolactin gene expression in leukocytes-potential implications in obesity.
|
29386559 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, in both PCOS and Non-PCOS daytime changes of prolactin level were higher in normal weight than overweight and obese women (35.8 ± 26.0 vs. 28.5 ± 25.4 vs. 23.2 ± 21.1 ng/mL and 24.3 ± 15.3 vs. 17.5 ± 8.8 vs. 18.4 ± 11.6 ng/mL, respectively).
|
28277129 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recently, evidence has accumulated that obesity, type 2 diabetes, and metabolic syndrome are associated with reduced levels of serum prolactin (PRL) in humans and rodents, raising the question of whether low PRL levels contribute to metabolic dysfunction.
|
27805870 |
2017 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In each study, we tested associations of rs4712652 (near-PRL), rs10508503 (near-PTER), rs1424233 (near-MAF) and rs1805081 (NPC1), or proxy variants (r (2)>0.8), with the odds of being overweight and obese, as well as with body mass index (BMI), percentage body fat (%BF) and waist circumference (WC).
|
22430306 |
2013 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We nominally replicated the association with obesity (BMI ≥30 kg/m(2)) of six SNPs in or near the FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 loci (1.28 ≤ odds ratio (OR) ≤ 1.35; 0.004 ≤ P ≤ 0.043).
|
21720444 |
2012 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings are of great importance towards understanding the etiology of obesity associated with hyperprolactinemia in humans as well as the role of PRL as a metabolic regulator in adipose tissue.
|
21989556 |
2011 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A common variant (rs4712652) adjacent to the prolactin gene was recently associated with obesity using a genome-wide association study.
|
20846890 |
2011 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the reduced adipose tissue LPL expression, being significantly correlated with the decrease in insulin and PRL, suggests a role of hyperinsulinemia and hyperprolactinemia in inducing and sustaining obesity.
|
18535540 |
2008 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
PRL should be recognized as an important adipokine whose release is regulated by insulin and is affected by obesity in a depot-specific manner.
|
18647802 |
2008 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
PRL release from subcutaneous adipose explants is attenuated during obesity, suggesting that adipose PRL production is altered by the metabolic state.
|
17587388 |
2007 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
We suggest that this previously unrecognized association of an impaired prolactin response to hypoglycaemia and upper body segment fatness may be useful for the investigation of the genetics of obesity.
|
2194712 |
1990 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
6 of the post-obese women had in addition both an impairment in prolactin output and a failure to increase their venous noradrenaline concentrations during hypoglycaemia.
|
6122854 |
1982 |