Disease: Severe Sepsis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.400 AlteredExpression disease BEFREE In patients with severe sepsis, low levels of activated protein C are associated with high morbidity and mortality. 26936869 2017
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.400 Biomarker disease BEFREE Since recombinant APC (Drotecogin alfa), originally approved for the treatment of severe sepsis, is not available for human MS studies, we tested the hypothesis that pharmacologic activation of endogenous protein C could likewise improve the outcome of EAE. 24810631 2015
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.400 Biomarker disease BEFREE Activated protein C (APC) inhibits inflammation and apoptosis in monocytes, and this may partly explain the protective effects of APC treatment in severe sepsis. 21166994 2011
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.400 Biomarker disease BEFREE These results suggest that the EPCR- and PAR-1-dependent protective effects of APC in severe sepsis may partially be mediated through the inhibition of HMGB1 signaling and that the chimeric thrombin mutant has potential therapeutic utility for severe sepsis. 21849480 2011
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.400 Biomarker disease BEFREE Therefore, the cytoprotective effects, rather than the anticoagulant effect of APC are postulated to be responsible for the therapeutic benefit of APC in the treatment of severe sepsis. 19995397 2010
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.400 AlteredExpression disease BEFREE The monitoring of plasma protein C activity and sufficient administration of activated protein C product could improve the outcome of severe sepsis in children. 18751723 2009
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.400 Biomarker disease BEFREE Activated protein C (APC) reduces mortality in severe sepsis patients. 19244160 2009
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.400 Biomarker disease BEFREE Protease activated receptor-1 (PAR1) mediates barrier protective signalling of activated protein C (APC) in human endothelial cells in vitro and may contribute to APC's beneficial effects in patients with severe sepsis. 19350118 2009
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.400 Biomarker disease BEFREE Conversion of protein C to APC is impaired in severe sepsis. 19498123 2009
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.400 AlteredExpression disease BEFREE These mutants provide useful tools for initiating in vivo studies to understand the extent to which the anticoagulant versus antiinflammatory activity of APC contributes to its beneficial effect in treating severe sepsis. 17580306 2007
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.400 Therapeutic disease CTD_human Prophylactic heparin in patients with severe sepsis treated with drotrecogin alfa (activated). 17556722 2007
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.400 Biomarker disease BEFREE Pharmacologic infusion of activated protein C (APC) improves survival in severe sepsis, and platelet factor 4 (PF4) accelerates APC generation in a primate thrombin-infusion model. 17540840 2007
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.400 Biomarker disease BEFREE Results of severe sepsis treatment program using recombinant human activated protein C in Poland. 16501420 2006
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.400 Biomarker disease BEFREE We sought to confirm that carriers of this prothrombotic factor V Leiden mutation do not have an increased risk of developing severe sepsis and that carriers with severe sepsis derive similar treatment benefit from recombinant human activated protein C (drotrecogin alfa [activated]) as non-factor V Leiden carriers. 15118525 2004
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.400 Therapeutic disease CTD_human Copper inhibits activated protein C: protective effect of human albumin and an analogue of its high-affinity copper-binding site, d-DAHK. 11820775 2002