|
Tauopathies
|
0.020 |
Biomarker
|
group |
BEFREE |
We previously investigated the disease-modifying potential of a microtubule-stabilising peptide NAP (NAPVSIPQ) in a well-established Drosophila model of tauopathy characterised by microtubule breakdown and axonal transport deficits.
|
27910888 |
2016 |
|
Amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage.
|
17478890 |
2007 |
|
Anxiety
|
0.010 |
Biomarker
|
disease |
BEFREE |
NAP but not Risperidone, reduced anxiety in the mutated mice.
|
26553741 |
2015 |
|
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
NAP but not Risperidone, reduced anxiety in the mutated mice.
|
26553741 |
2015 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we constructed a CTB-NAP fusion protein on the surface of Bacillus subtilis spore and evaluate the efficiency of oral administration of the recombinant CTB-NAP spores in preventing asthma in mice.
|
28608279 |
2017 |
|
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings tie for the first time a reduction in presynaptic glutamatergic synapses with the autism/Alzheimer's/schizophrenia-linked ADNP deficiency coupled with amelioration by NAP (CP201).
|
30664622 |
2019 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Down-regulation of a novel gene, DRLM, in human liver malignancy from 4q22 that encodes a NAP-like protein.
|
12383514 |
2002 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Whereas NAP application did not alleviate macroscopic (i.e. clinical) sequelae of colitis, lower numbers of apoptotic, but higher counts of proliferating/regenerating colonic epithelial cells could be observed in NAP as compared to placebo treated mice at day 7 p.i.
|
29288684 |
2018 |
|
Dental Pulp Necrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The maintenance of AP in molar teeth with necrotic pulp and apical periodontitis was associated with less postoperative pain when compared with NAP.
|
29370942 |
2018 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
What's more, the antidepressant effect in social isolation-rearing mice was observed after intranasal administration of NT4-NAP/AAV, suggesting that this might be a promising therapeutic strategy for depressive disorder.
|
28052034 |
2017 |
|
Drug Use Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Correlation, survival and path analyses of three consecutive assessments evaluated the relationships between parental DUD (number of affected parents, NAP), nutritional status (NS, subscapular skinfold measurements and body mass index), sexual maturation (Tanner stage), peer delinquency, and the daughter's lifetime DUD diagnosis.
|
25156223 |
2014 |
|
Eosinophilia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mucosal administration of HP-NAP was equally successful as the systemic delivery in reducing eosinophilia, IgE and Th2 cytokine levels in bronchoalveolar lavage.
|
18671823 |
2008 |
|
Disorder of eye
|
0.010 |
Biomarker
|
group |
BEFREE |
NAP exerts a protective effect in various eye diseases, including DR.
|
30374973 |
2019 |
|
Fatigue
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In particular, immediately after the 02-NAP, fatigue and high-frequency power (HF) were higher than after the 22-NAP.
|
31087442 |
2019 |
|
Fetal Alcohol Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Previously, we showed the treatment with NAP (NAPVSIPQ) + SAL (SALLRSIPA) reversed the learning deficit after prenatal alcohol exposure in FAS.
|
20446212 |
2010 |
|
Hepatitis C
|
0.010 |
Biomarker
|
disease |
BEFREE |
NAP HCV-RNA provides a consistent, standardized method for comparing results across laboratories and technologies and is useful in ensuring the quality of NAT testing for HCV RNA, independent of the methodology used.
|
11163581 |
2001 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum positivity and level of HP-NAP-specific antibodies in sera from 43 patients with gastric cancer, 28 with chronic gastritis, 28 with peptic ulcer, and 89 healthy controls were measured by rHP-NAP-based ELISA. rHP-NAP-stimulated production of interleukin-8 (IL-8) and growth-related oncogene (GRO(alpha)) cytokines in the culture supernatant of SGC7901 gastric epithelial cells was also detected.
|
19452583 |
2009 |
|
Mycoplasma Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Structural characterization of the NAP; the major adhesion complex of the human pathogen Mycoplasma genitalium.
|
28671286 |
2017 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
HP-NAP can mediate antitumor effects by recruiting neutrophils and inducing Th1-type differentiation in the tumor microenvironment.
|
23817216 |
2013 |
|
Pain, Postoperative
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The maintenance of AP in molar teeth with necrotic pulp and apical periodontitis was associated with less postoperative pain when compared with NAP.
|
29370942 |
2018 |
|
Periapical Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The maintenance of AP in molar teeth with necrotic pulp and apical periodontitis was associated with less postoperative pain when compared with NAP.
|
29370942 |
2018 |
|
Pheochromocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pheochromocytoma cells (PC12), exposed to high concentration of zinc (400µM), were used to determine the protective effect of NAP on Tau phosphorylation and two Tau kinases (Fyn and GSK-3β).
|
30417779 |
2018 |
|
Schizophrenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, the combination of NAP and standard of care Risperidone in humans may protect against language disturbances associated with negative and cognitive impairments in schizophrenia.
|
26553741 |
2015 |
|
Progressive supranuclear palsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Clinically, NAP (davunetide, CP201) exhibited efficacy in prodromal Alzheimer's disease patients (Tau3R/4R tauopathy) but not in progressive supranuclear palsy (increased Tau4R tauopathy).
|
30865715 |
2019 |
|
Tuberculosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A total of 1431 acid-fast bacilli (AFB) in Bactec culture vials from 1427 patients was differentiated by the Bactec NAP method and tested by the LCx Mycobacterium tuberculosis ligase chain reaction system.
|
12171305 |
2002 |