PROS1, protein S, 5627

N. diseases: 283; N. variants: 57
Disease: Activated Protein C Resistance ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600433
Disease: Activated Protein C Resistance
Activated Protein C Resistance 		0.400 Biomarker disease BEFREE APC resistance (13.4 %) was detected to be most common in Indian RPL patients followed by PS (10.6 %), PC (9.8 %) and AT deficiency (4.31 %.). 25771983 2015
CUI: C0600433
Disease: Activated Protein C Resistance
Activated Protein C Resistance 		0.400 GeneticVariation disease BEFREE These results support a role for platelet turnover, factor V, and aAPCR in the thrombosis of ET as well as the association between JAK2 V617F allele burden and either decreased free PS or increased TF and soluble markers of platelet and endothelial activation. 19105233 2009
CUI: C0600433
Disease: Activated Protein C Resistance
Activated Protein C Resistance 		0.400 AlteredExpression disease LHGDN Our objective was to study the effect of OC on the two main determinants of the APC-resistance test, free protein S and free tissue factor pathway inhibitor (TFPI). 18067603 2008
CUI: C0600433
Disease: Activated Protein C Resistance
Activated Protein C Resistance 		0.400 AlteredExpression disease LHGDN Thrombin generation and activated protein C resistance in patients with essential thrombocythemia and polycythemia vera. 18768782 2008
CUI: C0600433
Disease: Activated Protein C Resistance
Activated Protein C Resistance 		0.400 Biomarker disease BEFREE For congenital thrombophilia, tests evaluated comprised protein C (PC), protein S (PS), antithrombin (AT), and activated protein C resistance (APCR). 15706475 2005
CUI: C0600433
Disease: Activated Protein C Resistance
Activated Protein C Resistance 		0.400 GeneticVariation disease BEFREE Furthermore, the presence of anti-protein S Abs was strongly associated with acquired APC-R (OR, 57.8; 95% CI, 8.53-391; p < 0.0001). 12428083 2002
CUI: C0600433
Disease: Activated Protein C Resistance
Activated Protein C Resistance 		0.400 Biomarker disease CTD_human Hormone replacement therapy and acquired resistance to activated protein C: results of a randomized, double-blind, placebo-controlled trial. 11703344 2001
CUI: C0600433
Disease: Activated Protein C Resistance
Activated Protein C Resistance 		0.400 Biomarker disease BEFREE The lifetime risk for VTE was 4.4 for AT versus APCR, 2.6 for AT versus PS, 2.2 for AT versus PC, 1.9 for PC versus APCR, and 1.6 for PS versus APCR. 10195932 1999
CUI: C0600433
Disease: Activated Protein C Resistance
Activated Protein C Resistance 		0.400 Biomarker disease BEFREE Laboratory assays are currently available to diagnose and type hereditary thrombophilia due to deficiency or dysfunction of one of the anticoagulant factors antithrombin (AT), protein C (PC) and protein S (PS), and APC resistance without the need of DNA analysis. 9763348 1998
CUI: C0600433
Disease: Activated Protein C Resistance
Activated Protein C Resistance 		0.400 Biomarker disease BEFREE Thus, four families were diagnosed with the type I PS defect and five with congenital APC-R. No combined PS/FV Leiden or type II PS defect was found. 9518043 1997
CUI: C0600433
Disease: Activated Protein C Resistance
Activated Protein C Resistance 		0.400 Biomarker disease BEFREE Since the presence of activated protein C (APC) resistance has been reported to interfere with PS activity assays resulting in an apparent type II PS deficiency, we retrospectively tested a pre-transplantation frozen plasma sample for APC resistance. 8845465 1996
CUI: C0600433
Disease: Activated Protein C Resistance
Activated Protein C Resistance 		0.400 Biomarker disease BEFREE Subjects previously diagnosed as having functional PS deficiency should be re-investigated for APC resistance. 7803245 1994