PROS1, protein S, 5627

N. diseases: 283; N. variants: 57
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE PSA relapse was observed in one patient (1.08%) in the low-risk group (pelvic lymph node involvement was detected) and in seven patients (6.5%) in the intermediate-risk group (three lymph node metastases, two lymph node and bone metastases, two PSA relapses). 31486267 2019
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE SPDEF positivity was significantly associated with tumour stage, Gleason grade, lymph node metastasis and PSA recurrence (all P<0.0001). 31612022 2019
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE Prognostic factors for detecting lymph node/metastasis were identified in the group 2: PSA failure ≥ 1.37 ng/ml and PSADT < 4 months and in the group 3: PSADT < 4.6 months and time to failure < 5 years. 30448957 2019
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE RESULTS CXCR7 was upregulated in PCa tissues (P<0.05) and was correlated with PSA (P=0.023), differentiation (P=0.022), and lymph node metastasis (P=0.018). 30047547 2018
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE HSD3B2 up regulation was linked to advanced pathological tumor stage (pT), high Gleason grade, elevated preoperative PSA levels (p < 0.0001 each), lymph node metastasis (p = 0.0019), accelerated cell proliferation (p < 0.0001), androgen receptor (AR) expression (p < 0.0001), and early biochemical recurrence (p < 0.0001). 29803408 2018
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE PSCA expression was associated with favorable pathological and clinical tumor features: Early pathological tumor stage (p < 0.0001), low Gleason grade (p < 0.0001), absence of lymph node metastasis (p < 0.0001), low pre-operative PSA level (p = 0.0118), negative surgical margin (p < 0.0001) and reduced PSA recurrence (p < 0.0001). 29855276 2018
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE The low expression of EFEMP1 was obviously affected by Gleason's score, serum PSA, pathological stage, and lymph node metastasis. 28085790 2017
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE Drawbacks of PET/MR are a substantially longer imaging time and a slight inferiority in detecting bone and lymph node metastases in patients with PSA values >2 ng/ml. 28803358 2017
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE PCDH8 methylation was correlated with advanced clinical stage (P=0.021), higher level of preoperative PSA (P=0.008), and positive lymph node metastasis (P=0.010). 29026066 2017
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE Overexpression of CR-1 had close relationship with PSA, Gleason, clinical staging and lymph node metastasis in PCa patients. 28098905 2017
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE BGN protein expression rose with increasing pathological tumor stage, Gleason grade, lymph node metastasis and early PSA recurrence (P<.0001 each). 28830008 2017
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE PCA3 and PSA gene activity correlates with the true tumor cell burden in prostate cancer lymph node metastases. 25769446 2015
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE PSA levels were significantly correlated with the Gleason score, tumor stage, and lymph node metastasis with Spearman correlation coefficients: 0.612, 0.576, and 0.458. 25521481 2015
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE Then, low miR-128 expression in both PCa tissues and patients' sera were dramatically associated with aggressive clinicopathological features, including advanced pathological stage (both P=0.001), positive lymph node metastasis (P=0.006 and 0.01, respectively), high preoperative PSA (both P=0.01) and positive angiolymphatic invasion (both P=0.02). 26339409 2015
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE PCDH17 methylation was significantly associated with higher pathological Gleason score (P=0.0315), advanced pathological stage (P=0.0260), higher level of preoperative PSA (P=0.0354), positive angiolymphatic invasion (P=0.0461), positive lymph node metastasis (P=0.0362), and biochemical recurrence (BCR) (P=0.0018). 25091018 2014
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE Additionally, the loss of miR-126 expression was dramatically associated with aggressive clinical pathological features, including advanced pathological stage (P = 0.001), positive lymph node metastasis (P = 0.006), high preoperative PSA (P = 0.003) and positive angiolymphatic invasion (P = 0.001). 24350576 2013