DisGeNET - a database of gene-disease associations

PRPS1, phosphoribosyl pyrophosphate synthetase 1, 5631

N. diseases: 151; N. variants: 26

Disease: Malignant neoplasm of breast ×

Source: ALL

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Disease

Score _gda

Association Type

Type

Original DB

Sentence supporting the association

PMID

PMID Year

CUI:	C0006142
Disease:	Malignant neoplasm of breast

Malignant neoplasm of breast

0.310

Biomarker

disease

BEFREE

Thus, PRPS1 inhibition may afford a therapeutic approach to relapsed patients with breast cancer, resistant to chemotherapy.

28177767

2017

CUI:	C0006142
Disease:	Malignant neoplasm of breast

Malignant neoplasm of breast

0.310

GeneticVariation

disease

UNIPROT