|
Adenocarcinoma of lung (disorder)
|
0.300 |
Biomarker
|
disease |
CTD_human |
c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.
|
27602772 |
2016 |
|
Narcolepsy
|
0.140 |
AlteredExpression
|
disease |
BEFREE |
Altered surface expression of P2Y11 receptor with narcolepsy-associated mutations.
|
31450027 |
2019 |
|
Narcolepsy
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Six of the eight narcolepsy-associated P2Y11 mutations resulted in significant functional deficits in P2Y11 signalling through both Ca2+ and cAMP signalling pathways.
|
28460015 |
2017 |
|
Narcolepsy
|
0.140 |
AlteredExpression
|
disease |
BEFREE |
EIF3G is located in the narcolepsy risk locus and EIF3G expression correlates with PPAN and P2RY11 expression.
|
25669430 |
2015 |
|
Narcolepsy
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
|
24204295 |
2013 |
|
Narcolepsy
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association analysis shows a strong association between narcolepsy and polymorphisms in the TCRα locus and weaker associations within TNFSF4 (also called OX40L), Cathepsin H and the P2RY11-DNMT1 (purinergic receptor subtype P2Y11 to DNMT1, a DNA methytransferase) loci, suggesting an autoimmune basis.
|
23497937 |
2013 |
|
Narcolepsy
|
0.140 |
GeneticVariation
|
disease |
GWASDB |
Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
|
24204295 |
2013 |
|
Narcolepsy 1
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
EIF3G is associated with narcolepsy across ethnicities.
|
25669430 |
2015 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
P2Y11 receptor antagonist NF340 ameliorates inflammation in human fibroblast-like synoviocytes: An implication in rheumatoid arthritis.
|
31301116 |
2019 |
|
Coronary Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pharmacologic conditioning using P2Y11 agonist may be beneficial after cardiac transplantation in improving myocardial ischemia/reperfusion outcomes and decreasing graft rejection lesions.
|
30711276 |
2019 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude that inhibition of LPS-induced ATP release, removal of excessive extracellular ATP, or P2Y11 receptor antagonists may be potential therapeutic strategies to prevent T cell suppression and restore host immune function in sepsis.
|
30787105 |
2019 |
|
Myocardial Ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pharmacologic conditioning using P2Y11 agonist may be beneficial after cardiac transplantation in improving myocardial ischemia/reperfusion outcomes and decreasing graft rejection lesions.
|
30711276 |
2019 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude that inhibition of LPS-induced ATP release, removal of excessive extracellular ATP, or P2Y11 receptor antagonists may be potential therapeutic strategies to prevent T cell suppression and restore host immune function in sepsis.
|
30787105 |
2019 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The best performing texture parameters in differentiating CC-RCC from NC-RCC for each sequence included (area under the curve in parentheses): entropy at SSF 4 (0.807) on T2WI, SD at SSF 4 (0.814) on DWI b500, SD at SSF 6 (0.879) on DWI b1000, mean at SSF 0 (0.848) on ADC, skewness at SSF 2 (0.854) on T1WI and skewness at SSF 3 (0.908) on CM phase.
|
31300850 |
2019 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We found that in the presence of extracellular nucleotides cilia-dependent chemosensation of the nucleotides inhibited migration and invasion in normal ciliated cholangiocytes through a P2Y11 receptor and liver kinase B1 (LKB1)-phosphatase and tensin homolog-AKT-dependent mechanism.
|
30299561 |
2019 |
|
Oropharyngeal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Accuracy of the HPV status site-specific factor 10 (SSF-10) variable for patients with oropharyngeal cancers in the Iowa Cancer Registry, 2010-2014.
|
29934978 |
2018 |
|
Corneal pannus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Diagnostic performance of NG SSF image sets for the detection of prosthetic abnormalities (20 pannus and two paravalvular leaks) was greater than that of standard image sets (P < 0.05).
|
28966103 |
2017 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Carcinoma-specific expression of P2Y11 receptor and its contribution in ATP-induced purinergic signalling and cell migration in human hepatocellular carcinoma cells.
|
28418839 |
2017 |
|
Astrocytoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated receptor functionality of the P2Y11 A87T mutant using HEK293 and 1321N1 astrocytoma cells.
|
24524250 |
2014 |
|
Childhood Astrocytoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated receptor functionality of the P2Y11 A87T mutant using HEK293 and 1321N1 astrocytoma cells.
|
24524250 |
2014 |
|
Malignant Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In the Malmö diet and cancer AMI case-control study (n = 3732) the P2Y11 gene Thr-87 polymorphism was present in 19.8% of the controls and 22.9% in AMI patients (OR 1.21; P = 0.03).
|
17135283 |
2007 |
|
Acute myocardial infarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The common Ala-87-Thr polymorphism of the P2Y11 receptor is associated with AMI and increased levels of C-reactive protein.
|
17135283 |
2007 |
|
Primary malignant neoplasm
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In the Malmö diet and cancer AMI case-control study (n = 3732) the P2Y11 gene Thr-87 polymorphism was present in 19.8% of the controls and 22.9% in AMI patients (OR 1.21; P = 0.03).
|
17135283 |
2007 |