|
Abdominal Pain
|
0.120 |
Biomarker
|
phenotype |
BEFREE |
It is important to know the diagnostic accuracy of serum amylase, serum lipase, urinary trypsinogen-2, and urinary amylase for the diagnosis of acute pancreatitis, so that an informed decision can be made as to whether the person with abdominal pain has acute pancreatitis.
|
28431198 |
2017 |
|
Abdominal Pain
|
0.120 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abdominal Pain
|
0.120 |
Biomarker
|
phenotype |
BEFREE |
The trypsinogen-2 dipstick test was positive in 57 of 78 patients with acute pancreatitis (sensitivity, 73.1%) and in 6 of 16 patients with abdominal pain but without any evidence of acute pancreatitis (specificity, 62.5%).
|
30643362 |
2019 |
|
Abnormal enzyme/coenzyme activity
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormal thrombosis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Acute on chronic pancreatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute and chronic pancreatitis: A case-control study from India.
|
26110235 |
2015 |
|
Acute pancreatitis
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The results of pooled analyses showed that CLDN2 rs7057398, MORC4 rs12688220 and PRSS1-PRSS2 rs10273639 polymorphisms were all significantly associated with susceptibility to acute pancreatitis in Caucasians.
|
31163246 |
2020 |
|
Acute pancreatitis
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Here we analysed whether common variants in the CLDN2-MORC4 and the PRSS1-PRSS2 locus that increase recurrent AP and CP risk associate with AP.
|
29884332 |
2018 |
|
Acute pancreatitis
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Compared with the AP group, the AP+PD98059+siRNA group had decreased expression of DUSP1 in tissues, whereas the AP+PD98059 group had decreased serum expression levels of TNF‑α, IL‑1β, IL‑6, HMGB1, S100A12 and amylase, lipase and urinary trypsinogen‑2.
|
29393354 |
2018 |
|
Acute pancreatitis
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
We confirmed a robust association of polymorphism rs10273639 at PRSS1-PRSS2 with AP in the Russian population.
|
27846138 |
2017 |
|
Acute pancreatitis
|
0.070 |
Biomarker
|
disease |
BEFREE |
The trypsinogen-2 dipstick test was positive in 57 of 78 patients with acute pancreatitis (sensitivity, 73.1%) and in 6 of 16 patients with abdominal pain but without any evidence of acute pancreatitis (specificity, 62.5%).
|
30643362 |
2019 |
|
Acute pancreatitis
|
0.070 |
Biomarker
|
disease |
BEFREE |
In a prospective cohort, urinary trypsinogen-2 level > 500 μg/L independently predicted local complications of AP.
|
31039289 |
2019 |
|
Acute pancreatitis
|
0.070 |
Biomarker
|
disease |
BEFREE |
We included all studies that evaluated the diagnostic test accuracy of serum amylase, serum lipase, urinary trypsinogen-2, and urinary amylase for the diagnosis of acute pancreatitis.
|
28431198 |
2017 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found a weak association between the minor allele of the PRSS1-PRSS2-rs10273639 and an increased risk of developing PDAC (OR<sub>homozygous</sub> = 1.19, 95% CI 1.02-1.38, p = 0.023).
|
28913878 |
2018 |
|
Aortic Valve Insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association of mannose-binding lectin gene polymorphism but not of mannose-binding serine protease 2 with chronic severe aortic regurgitation of rheumatic etiology.
|
18400978 |
2008 |
|
Autosomal Dominant Hereditary Pancreatitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Bronchopulmonary Dysplasia
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
In infants who subsequently developed BPD (n = 18), we detected significantly higher concentrations of trypsinogen-2 during postnatal days 5 to 10 compared with those who survived without it.
|
12949286 |
2003 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Tissue expression of TATI and an elevated preoperative serum concentration of trypsin-2-API are strong independent prognostic factors in advanced epithelial ovarian cancer.
|
15269150 |
2004 |
|
Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
LHGDN |
Receiver-operating characteristics curve analysis showed that serum trypsinogen-2 had the highest accuracy in differentiating between cholangiocarcinoma and PSC.
|
17640760 |
2007 |
|
Collagenopathy, type 2 alpha 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we show that human trypsin-2 is also capable of cleaving the triple helix of human cartilage collagen type II.
|
16192646 |
2005 |
|
Colonic Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
These data demonstrate that TRY2 is the dominant TRY in colon tissue and suggest that up-regulation of TRY1 expression in colon tumors may be associated with a metastatic phenotype.
|
11391623 |
2001 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Differential display of cDNAs expressed by human colorectal tumor tissues compared with adjacent normal colonic mucosa identified an isoform of TRY (TRY2) up-regulated in colorectal cancers.
|
11391623 |
2001 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Diabetic Nephropathy
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Zymography, Western blotting, and immunofluorometric analysis of DNP urine showed a significant association especially between activation of MMP-9 as well as PMN-type MMP-8 and TRY-2.
|
18428024 |
2008 |