PRSS2, serine protease 2, 5645

N. diseases: 66; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0238339
Disease: Hereditary pancreatitis
Hereditary pancreatitis 		0.630 Biomarker disease CTD_human
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 Biomarker disease HPO
CUI: C4080064
Disease: Autosomal Dominant Hereditary Pancreatitis
Autosomal Dominant Hereditary Pancreatitis 		0.300 Biomarker disease CTD_human
CUI: C0030305
Disease: Pancreatitis
Pancreatitis 		0.140 Biomarker disease HPO
CUI: C0000737
Disease: Abdominal Pain
Abdominal Pain 		0.120 Biomarker phenotype HPO
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.100 Biomarker group HPO
CUI: C0015967
Disease: Fever
Fever 		0.100 Biomarker phenotype HPO
CUI: C0022346
Disease: Icterus
Icterus 		0.100 Biomarker phenotype HPO
CUI: C0023518
Disease: Leukocytosis
Leukocytosis 		0.100 Biomarker phenotype HPO
CUI: C0030299
Disease: Pancreatic Pseudocyst
Pancreatic Pseudocyst 		0.100 Biomarker disease HPO
CUI: C0032227
Disease: Pleural effusion disorder
Pleural effusion disorder 		0.100 Biomarker group HPO
CUI: C0038238
Disease: Steatorrhea
Steatorrhea 		0.100 Biomarker phenotype HPO
CUI: C0267963
Disease: Exocrine pancreatic insufficiency
Exocrine pancreatic insufficiency 		0.100 Biomarker disease HPO
CUI: C1842406
Disease: Pancreatic calcification
Pancreatic calcification 		0.100 Biomarker phenotype HPO
CUI: C4022560
Disease: Splanchnic vein thrombosis
Splanchnic vein thrombosis 		0.100 Biomarker disease HPO
CUI: C4022922
Disease: Abnormal enzyme/coenzyme activity
Abnormal enzyme/coenzyme activity 		0.100 Biomarker phenotype HPO
CUI: C4023452
Disease: Elevated C-reactive protein level
Elevated C-reactive protein level 		0.100 Biomarker phenotype HPO
CUI: C4025731
Disease: Abnormal thrombosis
Abnormal thrombosis 		0.100 Biomarker disease HPO
CUI: C4551632
Disease: Recurrent pancreatitis
Recurrent pancreatitis 		0.100 Biomarker disease HPO
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 Biomarker group BEFREE Tumor-associated trypsin-2 and matrix metalloprotease-9 (MMP-9) are associated with cancer, particularly with invasive squamous cell carcinomas. 18062964 2008
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 AlteredExpression phenotype BEFREE TRY2 mRNA was detected in all 6 colorectal tumor cell lines, whereas TRY1 mRNA was expressed only in the metastatic tumor lines, showing that the high levels of TRY expression in the metastatic tumor lines are likely due to up-regulation of TRY1. 11391623 2001
CUI: C0039103
Disease: Synovitis
Synovitis 		0.010 AlteredExpression disease BEFREE Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue. 16192646 2005
CUI: C0238339
Disease: Hereditary pancreatitis
Hereditary pancreatitis 		0.630 Biomarker disease GENOMICS_ENGLAND A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. 16699518 2006
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 Biomarker disease CTD_human A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. 16699518 2006
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.490 AlteredExpression disease LHGDN A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. 16699518 2006