|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
LHGDN |
Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl.
|
15776435 |
2005 |
|
Pancreatitis, Alcoholic
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.
|
28754779 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Acute pancreatitis
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Here we analysed whether common variants in the CLDN2-MORC4 and the PRSS1-PRSS2 locus that increase recurrent AP and CP risk associate with AP.
|
29884332 |
2018 |
|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Here we analysed whether common variants in the CLDN2-MORC4 and the PRSS1-PRSS2 locus that increase recurrent AP and CP risk associate with AP.
|
29884332 |
2018 |
|
Hereditary pancreatitis
|
0.630 |
GeneticVariation
|
disease |
ORPHANET |
Here we demonstrate a heterozygous hybrid PRSS2 (encoding anionic trypsinogen)/PRSS1 gene in a French white family with hereditary pancreatitis, by means of quantitative fluorescent multiplex PCR and RT-PCR analyses.
|
18461367 |
2008 |
|
Hereditary pancreatitis
|
0.630 |
GeneticVariation
|
disease |
BEFREE |
Here we demonstrate a heterozygous hybrid PRSS2 (encoding anionic trypsinogen)/PRSS1 gene in a French white family with hereditary pancreatitis, by means of quantitative fluorescent multiplex PCR and RT-PCR analyses.
|
18461367 |
2008 |
|
Tropical infectious disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, we characterize the structural and proteolytic attributes of serine protease 2 (SmSP2) from Schistosoma mansoni, one of the major species responsible for the tropical infectious disease, schistosomiasis.
|
29677188 |
2018 |
|
Collagenopathy, type 2 alpha 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we show that human trypsin-2 is also capable of cleaving the triple helix of human cartilage collagen type II.
|
16192646 |
2005 |
|
Pancreatitis, Chronic
|
0.490 |
Biomarker
|
disease |
CTD_human |
Hereditary chronic pancreatitis.
|
18206817 |
2008 |
|
Pancreatitis
|
0.140 |
Biomarker
|
disease |
LHGDN |
Hereditary pancreatitis caused by a double gain-of-function trypsinogen mutation.
|
18461367 |
2008 |
|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
However mutations in cationic and anionic trypsinogen gene do not play an important role in causing CP in Asia Pacific region.
|
21323990 |
2011 |
|
Pancreatic carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Hyperexpression of the PRSS2 gene and hypermethylation of ELA3B gene promoter were associated with PC, raising the possibility of their application as new biomarkers in PC diagnosis and screening.
|
20428826 |
2010 |
|
Malignant neoplasm of pancreas
|
0.020 |
Biomarker
|
disease |
BEFREE |
Hyperexpression of the PRSS2 gene and hypermethylation of ELA3B gene promoter were associated with PC, raising the possibility of their application as new biomarkers in PC diagnosis and screening.
|
20428826 |
2010 |
|
Acute pancreatitis
|
0.070 |
Biomarker
|
disease |
BEFREE |
In a prospective cohort, urinary trypsinogen-2 level > 500 μg/L independently predicted local complications of AP.
|
31039289 |
2019 |
|
Tongue Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, trypsin-2 over-expression enhanced tongue carcinoma cell invasion by various genetic and proteolytic mechanisms.
|
22909050 |
2012 |
|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis.
|
16699518 |
2006 |
|
Pancreatitis
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
In contrast, no pancreatitis-associated mutations have been found in the anionic trypsinogen gene (PRSS2), suggesting that this isoform might play a relatively unimportant role in pancreatitis.
|
14695529 |
2004 |
|
Bronchopulmonary Dysplasia
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
In infants who subsequently developed BPD (n = 18), we detected significantly higher concentrations of trypsinogen-2 during postnatal days 5 to 10 compared with those who survived without it.
|
12949286 |
2003 |
|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
In this study, we evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic RAP and CP.
|
26110235 |
2015 |
|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
It has been recently shown that a loss-of-function variant, c.571G>A (p.G191R), in the anionic trypsinogen (PRSS2) gene protects against chronic pancreatitis in European populations.
|
19052022 |
2009 |
|
Abdominal Pain
|
0.120 |
Biomarker
|
phenotype |
BEFREE |
It is important to know the diagnostic accuracy of serum amylase, serum lipase, urinary trypsinogen-2, and urinary amylase for the diagnosis of acute pancreatitis, so that an informed decision can be made as to whether the person with abdominal pain has acute pancreatitis.
|
28431198 |
2017 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Mannan-binding lectin (MBL) - associated serine protease 2 (MASP-2) co-activates the lectin pathway of complement in response to several viral infections.
|
27588826 |
2016 |
|
Infection caused by Human T-lymphotropic virus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mannose binding lectin and mannose binding lectin-associated serine protease-2 genes polymorphisms in human T-lymphotropic virus infection.
|
23861212 |
2013 |
|
Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults.
|
18582923 |
2008 |