KLK6, kallikrein related peptidase 6, 5653

N. diseases: 99; N. variants: 1
Disease: Multiple Sclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.040 Biomarker disease BEFREE Taken together, our findings demonstrate that Klk6 secreted by OLs plays a critical role in the pathogenesis of EAE/MS and that it might serve as a potential therapeutic target for MS. 29086442 2018
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.040 Biomarker disease BEFREE Recent studies provide a functional link between kallikrein 6 (Klk6) and the development and progression of disease in patients with multiple sclerosis (MS) and in its murine models. 25153387 2014
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.040 AlteredExpression disease BEFREE Elevated levels of KLK6 occur in actively demyelinating multiple sclerosis (MS) lesions and in cases of spinal cord injury (SCI), stroke, and glioblastoma. 23832758 2013
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.040 AlteredExpression disease LHGDN Activity of a newly identified serine protease in CNS demyelination. 12023317 2002