|
Polypoidal choroidal vasculopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Weaker association for PCV was observed at ARMS2-HTRA1 (P<sub>dif</sub>=4.39 × 10<sup>-4</sup>) and KMT2E-SRPK2(P<sub>dif</sub>=4.43 × 10<sup>-3</sup>), compared with tAMD.
|
28835638 |
2017 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Intravitreal delivery of an HTRA1 inhibitor (DPMFKLboroV) was effective (36% lesion reduction; P = 0.009) in preventing PCV initiation but ineffective in treating existing lesions.
|
28941979 |
2017 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we sequenced the whole HTRA1 gene and its promoter by direct sequencing in a Hong Kong Chinese PCV cohort.
|
27338780 |
2016 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gene-gene interaction of CFH, ARMS2, and ARMS2/HTRA1 on the risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in Chinese population.
|
25771815 |
2015 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Twelve polymorphisms at the ARMS2-HTRA1 locus showed significant differences between PCV and nAMD.
|
26081444 |
2015 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Significantly, interactions were identified among FPR1 rs78488639, CFH rs800292, and HTRA1 rs11200638 in both exudative AMD and PCV.
|
25277308 |
2014 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Significant associations with both nAMD and PCV were observed in 2 polymorphisms of ARMS2 and HTRA1 rs11200638, with different genotypic distributions between nAMD and PCV (p<0.001).
|
23326481 |
2013 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The variants in CFH, ARMS2 and near HTRA1 were strongly associated with both PCV (P < 10(-6), 10(-7) and 10(-7) respectively) and nAMD (P < 10(-6), 10(-16) and 10(-17) respectively).
|
23274582 |
2013 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
With meta-analyses, variants in four genes were found to be significantly associated with PCV: LOC387715 rs10490924 (n=9, allelic odds ratio [OR]=2.27, p<0.00001), HTRA1 rs11200638 (n=4, OR=2.72, p<0.00001), CFH rs1061170 (n=4, OR=1.72, p<0.00001), CFH rs800292 (n=5, OR=2.10, p<0.00001), and C2 rs547154 (n=3, OR=0.56, p=0.01).
|
22509112 |
2012 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The decreased biological function of vascular endothelial cells and the degradation of extracellular matrix proteins, such as fibronectin, may be involved in a contributory role for HTRA1 in PCV pathogenesis.
|
23056244 |
2012 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
LOC387715/HTRA1 variants and the response to combined photodynamic therapy with intravitreal bevacizumab for polypoidal choroidal vasculopathy.
|
21817962 |
2012 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There is a strong and consistent association of the ARMS2/HTRA1 locus with both exudative AMD and PCV, suggesting the two disorders share, at least partially, similar molecular mechanisms.
|
22491416 |
2012 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The PCV and control groups were genotyped for ARMS2 (rs10490924) and HTRA1 (rs11200638) polymorphisms.
|
21959923 |
2012 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association pattern and haplotype estimation in the ARMS2/HTRA1 region of Japanese patients with PCV were very similar to those of Japanese patients with typical nAMD.
|
21191724 |
2010 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms on polypoidal choroidal vasculopathy.
|
20688737 |
2010 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Four AMD-associated haplotype-tagging alleles (rs547154, rs1061170, rs1410996, rs10490924) in the 3 major loci, CFH, CFB/C2, and ARMS2/HTRA1, also were statistically significantly associated with the PCV phenotype (P<0.05).
|
20378180 |
2010 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SNPs rs3753394 and rs800292 of CFH and rs11200638 of HTRA1 are significantly associated with the risk of PCV in Chinese patients.
|
18515590 |
2008 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was no significant difference in the incidence of CFH Y402H (P = 0.598) and HTRA1 rs11200638 (P = 0.290) between eyes with typical exudative AMD and with PCV.
|
18939352 |
2008 |
|
Polypoidal choroidal vasculopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The LOC387715/HTRA1 variants are associated with PCV and wet AMD in the Japanese population.
|
17692272 |
2007 |