|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
276/455 patients were classified as MPO-ANCA positive MPA, 4/455 patients were classified as PR3-ANCA positive MPA, 124/455 were MPO-ANCA positive GPA and 51/455 were PR3-ANCA positive GPA.
|
29887327 |
2019 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Wegener's granulomatosis (WG) is a necrotizing vasculitis characterized by clonal expansions of T cells and production of antibodies against proteinase 3.
|
11838849 |
2002 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Granulomatosis with polyangiitis (Wegener's ) is a rare autoimmune disease associated with the presence of antibodies directed against neutrophil antigen, proteinase-3 (PR3).
|
22791638 |
2012 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Granulomatosis with polyangiitis (Wegener granulomatosis): A proteinase-3 driven disease?
|
28495524 |
2018 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Granulomatosis with polyangiitis (GPA) is an autoimmune vasculitis associated with anti-neutrophil-cytoplasmic antibodies (ANCA) against proteinase 3 leading to kidney damage.
|
31142442 |
2019 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Proteinase 3 (PR3), which is also called myeloblastin, the target autoantigen for antineutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis, is a serine proteinase stored in azurophil granules of human neutrophils.
|
10498622 |
1999 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Proteinase 3, the main autoantigen in Wegener's granulomatosis (WG), can degrade SLPI proteolytically.
|
12519404 |
2003 |
|
Granulomatosis with polyangiitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Proteinase 3 (PR3), a serine proteinase contained in neutrophil azurophilic granules, is considered a risk factor for vasculitides and rheumatoid arthritis when expressed on the outer leaflet of neutrophil plasma membrane and is the preferred target of antineutrophil cytoplasm autoantibodies (ANCA) in Wegener granulomatosis.
|
17712045 |
2007 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Proteinase 3 (PR3)-specific antineutrophil cytoplasmic antibodies (ANCA) are highly specific for the autoimmune small vessel vasculitis, Wegener's granulomatosis (WG).
|
20810247 |
2010 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCAs) are well-known serological markers for granulomatosis with polyangiitis, but their role as serological markers for inflammatory bowel disease remains uncertain.
|
29514409 |
2018 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Proteinase 3 (PR3) is the autoantigen in granulomatosis with polyangiitis, an autoimmune necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCAs).
|
29755460 |
2018 |
|
Granulomatosis with polyangiitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Proteinase 3 (P3), a serine protease expressed by myeloid cells, localized within azurophil granules, and also expressed on the cellular membrane of polymorphonuclear neutrophils (PMN), is the target of autoimmunity in granulomatosis with polyangiitis.
|
30021768 |
2018 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro.
|
8738804 |
1996 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
A 55-year-old Japanese man who had been undergoing maintenance haemodialysis was diagnosed with GPA via a pathologically proven nasal granuloma and proteinase 3-antineutrophil cytoplasmic antibody-positive status.He was started on 60 mg prednisolone.
|
31401575 |
2019 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
A new approach to the molecular characterization of the c-ANCA antigen in Wegener's granulomatosis.
|
8296666 |
1993 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
A number of linear regions of Proteinase 3 reacting with IgG antibodies in the sera of patients with Wegener's granulomatosis have now been identified.
|
8774549 |
1996 |
|
Granulomatosis with polyangiitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
All but one patient, who had concomitant C-ANCA seropositivity and granulomatosis with polyangiitis, had a favorable disease course with controlled inflammation using topical and/or systemic immunomodulatory therapy.
|
30230931 |
2019 |
|
Granulomatosis with polyangiitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Among antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV), granulomatosis with polyangiitis (GPA) and proteinase 3-ANCA-positive AAV (PR3-AAV) are prevalent in European populations, while microscopic polyangiitis (MPA) and myeloperoxidase-ANCA-positive AAV (MPO-AAV) are predominant in the Japanese.
|
27166610 |
2016 |
|
Granulomatosis with polyangiitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Among six patients without granuloma on nasal biopsy, three patients with only antineutrophil cytoplasmic antibody (ANCA) and chronic rhinosinusitis could be classified as GPA due to proteinase 3 (PR3)-ANCA (or cytoplasmic (C)-ANCA) positivity.
|
30887162 |
2019 |
|
Granulomatosis with polyangiitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Anti-neutrophil cytoplasmic autoantibodies (ANCA) targeting proteinase 3 (PR3) and myeloperoxidase expressed by innate immune cells (neutrophils and monocytes) are salient diagnostic and pathogenic features of small vessel vasculitis, comprising granulomatosis with polyangiitis (GPA), microscopic polyangiitis, and eosinophilic GPA.
|
29686675 |
2018 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Anti-neutrophil cytoplasmic autoantibodies recognizing conformational epitopes (c-ANCA) of proteinase 3 (PR3) from azurophil granules are a diagnostic hallmark in Wegener's granulomatosis (WG).
|
9187364 |
1997 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Antineutrophil cytoplasmic autoantibodies (ANCA) directed to proteinase 3 (PR3-ANCA) or myeloperoxidase (MPO-ANCA) are closely associated with the idiopathic systemic necrotizing vasculitides, in particular Wegener's granulomatosis, microscopic polyangiitis and its renal limited manifestation, and Churg Strauss Syndrome.
|
12849060 |
2002 |
|
Granulomatosis with polyangiitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of ETS1 polymorphism with granulomatosis with polyangiitis and proteinase 3-anti-neutrophil cytoplasmic antibody positive vasculitis in a Japanese population.
|
29167552 |
2018 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Autoantibodies against PR3 are an obligate feature in the pathogenesis of Wegener's granulomatosis, a systemic autoimmune vasculitis.
|
7952651 |
1994 |
|
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
By indirect antigen-capture ELISA using rpPR3, 60% of sera from patients with Wegener's granulomatosis bound to the recombinant product, although it was not recognized in ELISA with directly coated rpPR3.
|
9367410 |
1997 |