Granulomatosis with polyangiitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Among six patients without granuloma on nasal biopsy, three patients with only antineutrophil cytoplasmic antibody (ANCA) and chronic rhinosinusitis could be classified as GPA due to proteinase 3 (PR3)-ANCA (or cytoplasmic (C)-ANCA) positivity.
|
30887162 |
2019 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serum vasculitis panel (proteinase-3 antibody) supported the diagnosis of granulomatosis with polyangiitis.
|
30798274 |
2019 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Intravascular large B-cell lymphoma with a high titer of proteinase-3-anti-neutrophil cytoplasmic antibody mimicking granulomatosis with polyangiitis.
|
27398728 |
2019 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
A 55-year-old Japanese man who had been undergoing maintenance haemodialysis was diagnosed with GPA via a pathologically proven nasal granuloma and proteinase 3-antineutrophil cytoplasmic antibody-positive status.He was started on 60 mg prednisolone.
|
31401575 |
2019 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We included 35 proteinase 3-antineutrophil cytoplasmic antibodies-positive patients with GPA in a cross-sectional study.
|
30704507 |
2019 |
Granulomatosis with polyangiitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
All but one patient, who had concomitant C-ANCA seropositivity and granulomatosis with polyangiitis, had a favorable disease course with controlled inflammation using topical and/or systemic immunomodulatory therapy.
|
30230931 |
2019 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
There is a difference in mean age at onset and proteinase 3 (PR3) or myeloperoxidase (MPO) positivity in GPA patients from different Asian countries.
|
30338654 |
2019 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Minimal to mild CS predicted recovery of renal function at 1 year; clinical diagnosis (granulomatosis with polyangiitis versus MPA) and ANCA specificity (proteinase 3 versus MPO) did not.
|
30102330 |
2019 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Granulomatosis with polyangiitis (GPA) is an autoimmune vasculitis associated with anti-neutrophil-cytoplasmic antibodies (ANCA) against proteinase 3 leading to kidney damage.
|
31142442 |
2019 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
276/455 patients were classified as MPO-ANCA positive MPA, 4/455 patients were classified as PR3-ANCA positive MPA, 124/455 were MPO-ANCA positive GPA and 51/455 were PR3-ANCA positive GPA.
|
29887327 |
2019 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study was conducted retrospectively at Caen University Hospital and included all consecutive granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) patients with positive proteinase 3-ANCA or myeloperoxidase-ANCA, from January 2000 or September 2011, respectively, to June 2016.
|
30824651 |
2019 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Furthermore, the pathogenesis of ANCA-associated vasculitis has been reviewed with particular emphasis on the role of proteinase 3 (PR3) in fuelling granulomatosis with polyangiitis (GPA) inflammation.
|
31198793 |
2019 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Simulated B-factor analysis revealed that the binding of moANCA518 to iHm5-Val<sup>103</sup> was due to increased main-chain flexibility of the latent epitope caused by remote mutations, suggesting rigidification of epitopes with therapeutics to alter pathogenic PR3·ANCA interactions as new GPA treatments.
|
31708920 |
2019 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serological studies were positive for perinuclear antineutrophil antibodies specific to proteinase-3 antigen, and the patient was ultimately diagnosed with granulomatosis with polyangiitis.
|
29386209 |
2018 |
Granulomatosis with polyangiitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Anti-neutrophil cytoplasmic autoantibodies (ANCA) targeting proteinase 3 (PR3) and myeloperoxidase expressed by innate immune cells (neutrophils and monocytes) are salient diagnostic and pathogenic features of small vessel vasculitis, comprising granulomatosis with polyangiitis (GPA), microscopic polyangiitis, and eosinophilic GPA.
|
29686675 |
2018 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
To evaluate circulating cytokine profiles in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), classified by antineutrophil cytoplasmic antibody (ANCA) specificity (proteinase 3 ANCA [PR3-ANCA] versus myeloperoxidase ANCA [MPO-ANCA]) or by clinical diagnosis (granulomatosis with polyangiitis [GPA] versus microscopic polyangiitis [MPA]).
|
29693324 |
2018 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCAs) are well-known serological markers for granulomatosis with polyangiitis, but their role as serological markers for inflammatory bowel disease remains uncertain.
|
29514409 |
2018 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Granulomatosis with polyangiitis (Wegener granulomatosis): A proteinase-3 driven disease?
|
28495524 |
2018 |
Granulomatosis with polyangiitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of ETS1 polymorphism with granulomatosis with polyangiitis and proteinase 3-anti-neutrophil cytoplasmic antibody positive vasculitis in a Japanese population.
|
29167552 |
2018 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Membrane-bound proteinase 3 (PR3<sup>m</sup>) is the main target antigen of anti-neutrophil cytoplasmic autoantibodies (ANCA) in granulomatosis with polyangiitis, a systemic small-vessel vasculitis.
|
29925593 |
2018 |
Granulomatosis with polyangiitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Proteinase 3 (P3), a serine protease expressed by myeloid cells, localized within azurophil granules, and also expressed on the cellular membrane of polymorphonuclear neutrophils (PMN), is the target of autoimmunity in granulomatosis with polyangiitis.
|
30021768 |
2018 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Proteinase 3 (PR3) is the autoantigen in granulomatosis with polyangiitis, an autoimmune necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCAs).
|
29755460 |
2018 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Circulating anti-neutrophilic cytoplasmic autoantibodies targeting proteinase 3 (PR3-ANCA) are a diagnostic and pathogenic hallmark of granulomatosis with polyangiitis (GPA).
|
30054207 |
2018 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The small vessel vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis are associated with autoantibodies to neutrophil cytoplasm antigens (ANCA), principally proteinase-3 (PR3) and myeloperoxidase (MPO).
|
29447930 |
2018 |
Granulomatosis with polyangiitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We sought to characterize IgM ANCA more clearly by creating a novel enzyme-linked immunosorbent assay (ELISA) for IgM antibodies to proteinase 3 [IgM proteinase 3 (PR3)-ANCA], which we applied to two large, clinically well-characterized trial cohorts of patients with granulomatosis with polyangiitis and microscopic polyangiitis.
|
28076879 |
2017 |