PRTN3, proteinase 3, 5657

N. diseases: 215; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.100 Biomarker disease BEFREE Lip-kMA, a cationic liposome containing keto-MA, presented strong antitumor activity in two murine syngeneic graft models using the murine bladder cancer cell lines MB49 and MBT-2 in comparison to both Lip-aMA and Lip-mMA, which contained α-MA and methoxy-MA, respectively. 30608942 2019
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.100 Biomarker disease BEFREE Currently, MBT-2 is the most common murine bladder cancer cell line used in orthotopic bladder cancer models, even though this cell type often has an inappropriate genetic mutation landscape. 28881578 2017
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.100 Biomarker disease BEFREE Endogenous expression of Aggrus protein on the cell surface was found in the mouse bladder cancer MBT-2 cell line and human bladder cancer SCaBER cell lines. 24222607 2014
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.100 Biomarker disease BEFREE Combination of IDO shRNA and OSU-HDAC42 increased antitumor effect of IDO shRNA in MBT-2 murine bladder tumor model. 23681283 2013
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.100 Biomarker disease BEFREE Systemic transduction of p16INK4A antitumor peptide inhibits the growth of MBT-2 mouse bladder tumor cell line grafts. 23292502 2013
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.100 AlteredExpression disease BEFREE Of several bladder cancer cell lines UMUC3 and MBT-2 markedly expressed androgen receptor transcript and protein. 22608749 2012
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.100 GeneticVariation disease BEFREE Next, we examined the role of metastin in the invasiveness and lung metastasis of MBT-2 variant (MBT-2V), which is a highly metastatic murine bladder cancer cell. 22367780 2012
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.100 Biomarker disease BEFREE Compared to BCG-stimulated C3H/HeN macrophages, BCG-stimulated C57BL/6 macrophages exhibited reduced killing of bladder cancer MBT-2 cells and MB49 cells. 20148913 2010
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.100 Biomarker disease BEFREE To evaluate the antitumor effects of recombinant bacille Calmette-Guérin (BCG) DNA (multi-rBCG) and murine interleukin-12 DNA (mIL-12) vaccines on xenografted MBT-2 murine bladder tumors. 15028475 2004
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.100 Biomarker disease BEFREE In vitro: 3 human (5637, RT-4 and TCC-SUP) and one murine (MBT-2) bladder cancer cell line were exposed to ADV/RSV-tk or ADV/CMV-tk vectors and cell survival was determined. 11062688 2000
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.100 Biomarker disease BEFREE Pure soy isoflavones (genistein, genistin, daidzein, and biochanin A) and soy phytochemical concentrate exhibit dose-dependent growth inhibition of murine (MB49 and MBT-2) and human (HT-1376, UM-UC-3, RT-4, J82, and TCCSUP) bladder cancer cell lines, although the degree of inhibition varies among lines. 9823337 1998
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.100 Biomarker disease BEFREE The mouse MBT-2 tumor used is an excellent model for human bladder cancer. 8459207 1993