PRTN3, proteinase 3, 5657

N. diseases: 215; N. variants: 3
Disease: Pancreatitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030305
Disease: Pancreatitis
Pancreatitis 		0.110 AlteredExpression disease BEFREE CTSC deletion reduced the severity of pancreatitis (more prominently in the milder model) without directly affecting intra-acinar cell trypsin activation <i>in vitro</i> The absence of CTSC reduced infiltration of neutrophil granulocytes impaired their capacity for cleaving E-cadherin in adherens junctions between acinar cells and reduced the activity of neutrophil serine proteases polymorphonuclear (neutrophil) elastase, cathepsin G, and proteinase 3, but not neutrophil motility. 30455353 2019
CUI: C0030305
Disease: Pancreatitis
Pancreatitis 		0.110 Biomarker disease HPO