Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
All vasculitis relapses in the belimumab group (n = 6) occurred in patients who had PR3-ANCA-associated vasculitis with cyclophosphamide-induced disease remission.
|
30666823 |
2019 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Serum vasculitis panel (proteinase-3 antibody) supported the diagnosis of granulomatosis with polyangiitis.
|
30798274 |
2019 |
Vasculitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Of 85 patients with ANCA and vasculitis included in this study, 67 (78.8%) had MPO-ANCA, 10 (11.8%) had PR3-ANCA, and 8 (9.4%) had both MPO- and PR3-ANCA.
|
31552433 |
2019 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
<i>Conclusion</i>: In contrast to typical C-ANCA and P-ANCA, atypical P-ANCA seropositivity was not associated with severe vasculitis or poor prognosis in patients with the OID.
|
30230931 |
2019 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
None of the patients who were PR3-positive developed vasculitis.
|
31181198 |
2019 |
Vasculitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Measuring Circulating Complement Activation Products in Myeloperoxidase- and Proteinase 3-Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
|
31215772 |
2019 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
The proportion of patients who had no evidence of vasculitis among all patients with a positive C-ANCA/PR3 or P-ANCA/MPO was calculated according to tertiles of enzyme-linked immunosorbent assay (ELISA) antibody levels.
|
30729688 |
2019 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
ANCAs directed to proteinase 3 and myeloperoxidase (MPO) in particular are associated with distinct forms of small vessel vasculitides.
|
31719144 |
2019 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
All patients with active vasculitis and positive proteinase 3 (PR3)-ANCA who were starting a 2-year treatment course of rituximab for induction of remission at Addenbrooke's Hospital between January 2011 and January 2016 were included in this study.
|
30896460 |
2019 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
No further features of vasculitis emerged and PR3-ANCA titres declined.
|
30340563 |
2018 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
S100A12 Serum Levels and PMN Counts Are Elevated in Childhood Systemic Vasculitides Especially Involving Proteinase 3 Specific Anti-neutrophil Cytoplasmic Antibodies.
|
30533405 |
2018 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
We will next depict how the structural and enzymatic properties of proteinase 3 (PR3), the autoantigen in vasculitis, allow its expression on apoptotic neutrophils, which in turn affects efferocytosis and immune response associated with the clearance of apoptotic cells.
|
30039869 |
2018 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Clearly, though, the new testing strategy for ANCA in vasculitis must identify the ANCA target antigen, as PR3- and MPO-ANCA serotype correlate well with disease expression.
|
29395165 |
2018 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
The small vessel vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis are associated with autoantibodies to neutrophil cytoplasm antigens (ANCA), principally proteinase-3 (PR3) and myeloperoxidase (MPO).
|
29447930 |
2018 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
General, cutaneous and renal manifestations were commonly observed in MPO-ANCA vasculitis, while mucous membrane, eye, ear nose throat (ENT) and renal manifestations were often documented in PR3-ANCA vasculitis.
|
28339364 |
2017 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Anti-PR3 and cANCA were highly specific in primary vasculitis (P<0.01).
|
28878204 |
2017 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
ANCA vasculitis is associated with ANCA specific for myeloperoxidase (MPO-ANCA) or proteinase 3 (PR3-ANCA).
|
28842398 |
2017 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In order to provide an update on the recent advances in the pathogenesis, clinical features and novel treatments of lung involvement in systemic vasculitis, a systematic MedLine search has been performed.Most of the data analyzed have confirmed that lung involvement seems to develop more frequently in patients with myeloperoxidase-ANCA-positive AAV, mainly in those with a diagnosis of microscopic polyangiitis (MPA), compared with patients with proteinase 3 ANCA-positive AAV.
|
27755177 |
2017 |
Vasculitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of Serum Calprotectin (S100A8/A9) Level With Disease Relapse in Proteinase 3-Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
|
27428710 |
2017 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In the vasculitis cohort, CLIA performed well at clinically important stages of disease; diagnosis (eight samples all positive by both assays) and disease relapse (correlation for both MPO and PR3 antibody quantitation r<sub>s</sub> = 0.84, p = 0.03 and r<sub>s</sub> = 0.78, p < 0.01, respectively).
|
28549721 |
2017 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Interstitial pneumonia was more frequent in MPO-ANCA vasculitis (52.3% versus 5.9%, p < 0.01), whereas nodular shadow was more frequent in PR3-ANCA vasculitis (9.1% versus 58.8%, p < 0.01).
|
27320904 |
2017 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Importantly, TNFα can induce leucocyte cell membrane expression of the autoantigens involved in vasculitis [proteinase 3 and myeloperoxidase (MPO)], thus priming cells for the effects of ANCA.
|
28391344 |
2017 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Anti-neutrophil cytoplasmic antibody (ANCA) vasculitis is characterized by the presence of autoantibodies to myeloperoxidase and proteinase-3, which bind monocytes in addition to neutrophils.
|
28138552 |
2017 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Histone modification signature at myeloperoxidase and proteinase 3 in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis.
|
27752292 |
2016 |
Vasculitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Moreover, we identified genetic distinctions between granulomatosis with polyangiitis and microscopic polyangiitis and between proteinase 3 ANCA vasculitis and myeloperoxidase ANCA vasculitis.
|
26443607 |
2016 |