|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
No proteinase 3-ANCA was detected in all MPA patients with CPS.
|
31573728 |
2020 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study was conducted retrospectively at Caen University Hospital and included all consecutive granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) patients with positive proteinase 3-ANCA or myeloperoxidase-ANCA, from January 2000 or September 2011, respectively, to June 2016.
|
30824651 |
2019 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
276/455 patients were classified as MPO-ANCA positive MPA, 4/455 patients were classified as PR3-ANCA positive MPA, 124/455 were MPO-ANCA positive GPA and 51/455 were PR3-ANCA positive GPA.
|
29887327 |
2019 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Minimal to mild CS predicted recovery of renal function at 1 year; clinical diagnosis (granulomatosis with polyangiitis versus MPA) and ANCA specificity (proteinase 3 versus MPO) did not.
|
30102330 |
2019 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The small vessel vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis are associated with autoantibodies to neutrophil cytoplasm antigens (ANCA), principally proteinase-3 (PR3) and myeloperoxidase (MPO).
|
29447930 |
2018 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To evaluate circulating cytokine profiles in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), classified by antineutrophil cytoplasmic antibody (ANCA) specificity (proteinase 3 ANCA [PR3-ANCA] versus myeloperoxidase ANCA [MPO-ANCA]) or by clinical diagnosis (granulomatosis with polyangiitis [GPA] versus microscopic polyangiitis [MPA]).
|
29693324 |
2018 |
|
Microscopic Polyarteritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We reviewed the medical records of 133 patients with microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic GPA (EGPA), who had either myeloperoxidase (MPO)-ANCA, proteinase 3 (PR3)-ANCA or no ANCA, and who had ever achieved the first remission.
|
28339364 |
2017 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We sought to characterize IgM ANCA more clearly by creating a novel enzyme-linked immunosorbent assay (ELISA) for IgM antibodies to proteinase 3 [IgM proteinase 3 (PR3)-ANCA], which we applied to two large, clinically well-characterized trial cohorts of patients with granulomatosis with polyangiitis and microscopic polyangiitis.
|
28076879 |
2017 |
|
Microscopic Polyarteritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to provide an update on the recent advances in the pathogenesis, clinical features and novel treatments of lung involvement in systemic vasculitis, a systematic MedLine search has been performed.Most of the data analyzed have confirmed that lung involvement seems to develop more frequently in patients with myeloperoxidase-ANCA-positive AAV, mainly in those with a diagnosis of microscopic polyangiitis (MPA), compared with patients with proteinase 3 ANCA-positive AAV.
|
27755177 |
2017 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV), granulomatosis with polyangiitis (GPA) and proteinase 3-ANCA-positive AAV (PR3-AAV) are prevalent in European populations, while microscopic polyangiitis (MPA) and myeloperoxidase-ANCA-positive AAV (MPO-AAV) are predominant in the Japanese.
|
27166610 |
2016 |
|
Microscopic Polyarteritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, we identified genetic distinctions between granulomatosis with polyangiitis and microscopic polyangiitis and between proteinase 3 ANCA vasculitis and myeloperoxidase ANCA vasculitis.
|
26443607 |
2016 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ANCA directed against proteinase 3 (PR3) are preferentially associated with GPA, and anti-myeloperoxidase (MPO) ANCA are associated mainly with MPA and eosinophilic GPA (formerly known as Churg-Strauss syndrome).
|
24737903 |
2014 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, these studies have also shown that different AAV subtypes such as granulomatosis with polyangiitis (Wegener's, GPA) and microscopic polyangiitis (MPA) are underpinned by distinct genetic risk factors, with GPA being associated with HLA-DP, SERPINA1 (encoding α1-antitrypsin), PRTN3 (encoding proteinase-3, PR3, the main GPA-related autoantigen) and SEMA6A (semaphorin 6A), whereas MPA has been mainly associated with HLA-DQ.
|
24854378 |
2014 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ANCA directed against proteinase 3 (PR3) are preferentially associated with GPA, and anti-myeloperoxidase (MPO) ANCA are associated mainly with MPA and eosinophilic GPA (formerly known as Churg-Strauss syndrome).
|
23606701 |
2013 |
|
Microscopic Polyarteritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The distinct associations of PR3-ANCA and MPO-ANCA with different HLA class II antigens, which are stronger than those with the associated diseases, suggest a pathogenic role for those ANCAs and indicate that GPA and MPA are different diseases.
|
23810690 |
2013 |
|
Microscopic Polyarteritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Patients with AAV (n=105) subgrouped as microscopic polyangiitis or granulomatosis with polyangiitis (Wegener's granulomatosis) and myeloperoxidase (MPO) or proteinase 3 (PR3) ANCA positive were compared to a control group of 200 blood donors.
|
24356554 |
2013 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study confirms that the pathogenesis of ANCA-associated vasculitis has a genetic component, shows genetic distinctions between granulomatosis with polyangiitis and microscopic polyangiitis that are associated with ANCA specificity, and suggests that the response against the autoantigen proteinase 3 is a central pathogenic feature of proteinase 3 ANCA-associated vasculitis.
|
22808956 |
2012 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Wegener's granulomatosis, microscopic polyangiitis and Churg Strauss syndrome are small-vessel vasculitides associated with anti-neutrophil cytoplasmic antibodies (ANCA) directed against proteinase 3 (PR3) and myeloperoxidase (MPO).
|
17521322 |
2007 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cytoplasmic (c)-ANCA mainly target proteinase 3 (PR3) and are often observed in WG patients, while perinuclear (p)-ANCA predominantly bind to myeloperoxidase (MPO) and are common in patients with MPA and CSS.
|
15675141 |
2004 |
|
Microscopic Polyarteritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antineutrophil cytoplasmic autoantibodies (ANCA) directed to proteinase 3 (PR3-ANCA) or myeloperoxidase (MPO-ANCA) are closely associated with the idiopathic systemic necrotizing vasculitides, in particular Wegener's granulomatosis, microscopic polyangiitis and its renal limited manifestation, and Churg Strauss Syndrome.
|
12849060 |
2002 |