|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
All vasculitis relapses in the belimumab group (n = 6) occurred in patients who had PR3-ANCA-associated vasculitis with cyclophosphamide-induced disease remission.
|
30666823 |
2019 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-neutrophil cytoplasmic autoantibodies (ANCA) directed against myeloperoxidase (MPO) and proteinase 3 (PR3) are pathogenic in ANCA-associated vasculitis (AAV).
|
30818380 |
2019 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Exploring Frequencies of Circulating Specific Th17 Cells against Myeloperoxidase and Proteinase 3 in ANCA Associated Vasculitis.
|
31756913 |
2019 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the pathogenesis of ANCA-associated vasculitis has been reviewed with particular emphasis on the role of proteinase 3 (PR3) in fuelling granulomatosis with polyangiitis (GPA) inflammation.
|
31198793 |
2019 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Myeloperoxidase ANCA is more common than proteinase-3 ANCA, and glomerulonephritis is the most common clinical presentation of ANCA-associated vasculitis in SSc.
|
31776158 |
2019 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance.
|
31142442 |
2019 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, PR3 is a serine protease whose membrane expression can potentiate inflammatory diseases such as ANCA-associated vasculitis and rheumatoid arthritis.
|
29755460 |
2018 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, patients with proteinase 3 (PR3)-AAV may respond better to rituximab than cyclophosphamide.
|
28785984 |
2018 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review gives a brief overview on current knowledge about genetic and epigenetic factors, barrier dysfunction and chronic non-resolving inflammation, necro-inflammatory auto-amplification of cellular death and inflammation, altered autoantigen presentation, alternative complement pathway activation, alterations within peripheral and inflamed tissue-residing T- and B-cell populations, ectopic lymphoid tissue neoformation, the characterization of PR3-specific T-cells, properties of ANCA, links between autoimmune disease and infection-triggered pathology, and animal models in AAV.
|
29686675 |
2018 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
As dependable immunoassays for PR3-ANCAs and MPO-ANCAs have become broadly available, there is increasing international agreement that high-quality immunoassays are the preferred screening method for the diagnosis of ANCA-associated vasculitis.
|
28905856 |
2017 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To establish a link between DNA methylation, a model epigenetic gene silencing modification, and autoantigen gene expression and disease status in ANCA-associated vasculitis, we measured gene-specific DNA methylation of the autoantigen genes myeloperoxidase (<i>MPO</i>) and proteinase 3 (<i>PRTN3</i>) in leukocytes of patients with ANCA-associated vasculitis observed longitudinally (<i>n</i>=82) and of healthy controls (<i>n</i>=32).
|
27821628 |
2017 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our comparison of various ANCA detection methods showed (i) large variability between the two IIF methods tested and (ii) a high diagnostic performance of PR3-ANCA and MPO-ANCA by immunoassay to discriminate AAV from disease controls.
|
27481830 |
2017 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antibodies to myeloperoxidase (MPO) and proteinase 3 (PR3) are vital in the diagnosis and management of ANCA-associated vasculitis.
|
28549721 |
2017 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification and phenotyping of circulating autoreactive proteinase 3-specific B cells in patients with PR3-ANCA associated vasculitis and healthy controls.
|
28870527 |
2017 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The association of transient IgM PR3-ANCA with an acute respiratory manifestation of AAV suggests a possible link between an infectious trigger and AAV disease activity.
|
28076879 |
2017 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
C3c was found in 78 of 187 renal biopsies (41.7%) divided over 32.3% of proteinase-3 (PR3)-AAV patients and 52.3% of myeloperoxidase (MPO)-AAV patients (P = 0.006), whereas C3d was found positive in 51.1% of PR3-AAV patients and 70.4% of MPO-AAV patients (P = 0.105).
|
26275893 |
2017 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ANCA-associated vasculitis(AAV) covers a group of systemic necrotising vasculitides characterised by inflammation of small vessels, sometimes with granuloma, and associated with autoantibodies to neutrophil cytoplasmic proteases (proteinase-3 or myeloperoxidase).
|
28406765 |
2017 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of KDM6B mRNA is elevated in leukocytes from patients with ANCA-associated vasculitis (AAV) and has been suggested to be the reason for higher proteinase 3 (PR3) mRNA expression in these cells due to derepression of PRTN3 gene transcription.
|
27755585 |
2016 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A recent genome-wide association study of patients with ANCA-associated vasculitides confirmed the genetic contribution to the pathogenesis of these conditions, with significant association of PR3-ANCA and human leukocyte antigen-DP and the genes encoding α1-antitrypsin and PR3.
|
24737903 |
2014 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, these studies have also shown that different AAV subtypes such as granulomatosis with polyangiitis (Wegener's, GPA) and microscopic polyangiitis (MPA) are underpinned by distinct genetic risk factors, with GPA being associated with HLA-DP, SERPINA1 (encoding α1-antitrypsin), PRTN3 (encoding proteinase-3, PR3, the main GPA-related autoantigen) and SEMA6A (semaphorin 6A), whereas MPA has been mainly associated with HLA-DQ.
|
24854378 |
2014 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A recent genome-wide association study of patients with ANCA-associated vasculitides confirmed the genetic contribution to the pathogenesis of these conditions, with significant association of PR3-ANCA and human leukocyte antigen-DP and the genes encoding α1-antitrypsin and PR3.
|
23606701 |
2013 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study confirms that the pathogenesis of ANCA-associated vasculitis has a genetic component, shows genetic distinctions between granulomatosis with polyangiitis and microscopic polyangiitis that are associated with ANCA specificity, and suggests that the response against the autoantigen proteinase 3 is a central pathogenic feature of proteinase 3 ANCA-associated vasculitis.
|
22808956 |
2012 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The neutrophil serine protease proteinase 3 (PR3) is a main autoantigen in anti-neutrophil cytoplasmic antibody-associated vasculitis.
|
18462208 |
2008 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The data suggest that G-463A polymorphism does not seem to contribute to either MPO-ANCA- or PR3-ANCA-associated vasculitis formation.
|
15031357 |
2004 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alpha-1 anti-trypsin is the physiological inhibitor of PR3 and carriage of the defective allele PI*Z was observed as the first genetic risk factor for the development of PR3-ANCA-associated vasculitis.
|
15675141 |
2004 |