RETN, resistin, 56729

N. diseases: 302; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE In addition, plasma resistin level was associated with dyslipidaemia, serum insulin concentration and obesity. 19727657 2010
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE We conclude that the recently described relationships of murine resistin/Fizz3 expression with obesity, insulin resistance, and PPAR-gamma action may not readily translate to humans. 11574398 2001
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE Visfatin/PBEF/Nampt and resistin expressions in circulating blood monocytes are differentially related to obesity and type 2 diabetes in humans. 20091460 2010
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE The adipokine resistin has been proposed to link obesity, insulin resistance and diabetes. 30353146 2018
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Obesity is associated with an increased risk of colorectal cancer (CRC), and ghrelin (GHRL) and resistin (RETN) are thought to be related to obesity. 24585435 2014
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE Obesity is not associated with GCF and salivary resistin and TNF-α levels in children in the presence of gingival inflammation. 29635809 2018
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE This study was designed to estimate the possibility of utilizing psoriasin, nestin, keratin-16 (Krt16), and interleukin-21 (IL-21) as biochemical markers of psoriasis, to correlate these candidate psoriatic markers with biomarkers of obesity [body mass index (BMI), leptin, and resistin], and to elucidate the bidirectional association between obesity and psoriasis. 29252076 2018
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Thus, the overproduction of obesity‑associated resistin and the associated amplification of the inflammatory response may result in the aggravation of AP severity. 27959400 2017
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. 11978666 2002
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE The adipokine resistin is suggested to be an important link between obesity and insulin resistance. 15843582 2005
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Although resistin was recently found to modulate insulin resistance in preclinical models of type II diabetes and obesity, recent studies also suggested that resistin has proinflammatory properties. 24719460 2014
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Resistin may be an important link between obesity and diabetes. 25656506 2015
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Several clinical and experimental studies have identified resistin as a key hormone linking insulin-resistance to obesity, notably through the activation of Toll Like Receptor (TLR) 4 signaling pathways. 30906281 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE However, some recent genetic studies have demonstrated an association between resistin and insulin resistance and obesity. 12444887 2002
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE In conclusion, this study confirms the expression of resistin in human adipose tissue and increased expression in abdominal fat, this suggests a potential role in linking central obesity to type 2 diabetes and/or cardiovascular disease. 11994397 2002
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE In this study, we hypothesized that mutations in the resistin encoding gene, RETN, may cause a monogenic form of obesity. 21441316 2011
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE Genetic variations of the human RETN gene are associated with metabolic phenotypes, including obesity, insulin sensitivity, diabetes, and coronary heart disease (CHD). 19381781 2009
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia. 28421328 2017
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Resistin, an adipocyte secreted factor, has been suggested to link obesity with type 2 diabetes in rodent models, but its relevance to human diabetes remains uncertain. 14671216 2003
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE DNAJC27 was found to be associated with leptin and resistin, adipokines known to be dysregulated in obesity, that stimulate inflammatory processes leading to metabolic disorders. 30131766 2018
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Resistin promotes hypothalamic neuroinflammation and insulin resistance through Toll like receptor 4 (TLR4), this hormone is thought to be a link between obesity and insulin-resistance. 30845245 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE While resistin was first known as an adipocyte-secreted hormone (adipokine) linked to obesity and insulin resistance in rodents, it is predominantly expressed and secreted by macrophages in humans. 28192887 2017
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE Amplified resistin expression may indicate insulin-resistant type II diabetes and obesity are associated with AA breast cancer. 24324792 2013
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE The aim of this study was to investigate the association between the RANKL and c-Fos gene methylation on obesity with body mass index (BMI), lipid parameters, homeostasis model assessment of insulin resistance (HOMA-IR), plasma leptin, adiponectin and resistin levels. 31364017 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Resistin (<i>RETN</i>) is an adipokine that is associated with obesity, inflammation, and various cancers. 30406149 2018