Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Peptide-YY (PYY) and Glucagon-Like Peptide-1 (GLP-1) play important roles in the regulation of food intake and insulin secretion, and are of translational interest in the field of obesity and diabetes.
|
29311617 |
2018 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, the current review aims to compile, evaluate and summarise current knowledge on PYY, with particular emphasis on obesity and diabetes treatment, and the importance of specific Y receptor interactions for this.
|
29412828 |
2018 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
GLP-1 and PYY are higher during the light cycle in LEAN animals and AMY is higher in the OBESE group throughout the light/dark cycle.
|
29191090 |
2017 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The discovery of this alternative circuit that regulates ingestive behavior without inducing taste aversion may open the possibility of a therapeutic application of PYY for the treatment of obesity via direct oral application.
|
24259562 |
2013 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, adiponectin and omentin from subcutaneous fat displayed correlations with decreased obesity and increased insulin sensitivity while visfatin showed an association with serum PYY and weight gain.
|
25453978 |
2014 |
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
A PYY Q62P variant linked to human obesity.
|
16368708 |
2006 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
PYY and GLP-1 are implicated in regulation of gut motility, food intake and insulin secretion, and are of great interest regarding obesity and type 2 diabetes.
|
27405092 |
2017 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, prebiotics influence metabolism, and in obesity they increase the expression of anorexigenic gut hormones such as peptide tyrosine tyrosine, glucagon-like peptide 1 and leptin, as well as decrease levels of orexigenic hormones such as ghrelin.
|
29883788 |
2018 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
FFAs are candidate drug targets for increasing the secretion of intestinal hormones such as glucagon-like peptide-1 and peptide YY as potential new treatments for type 2 diabetes and obesity.
|
29688303 |
2018 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Taken together, these results are the first to support that rare sequence variants within PYY can influence human susceptibility to obesity.
|
16368708 |
2006 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
To verify whether peptide YY (PYY) and its Y2 receptor (Y2R) gene variants can be associated with obesity or hypertension or both in a cohort of obese children and adolescents.
|
18622237 |
2008 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
PYY, along with few other gut hormones, has been suggested as a potential therapeutic agent for obesity.
|
18441153 |
2008 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Changes in PYY concentrations were examined in obese patients after bariatric surgery and compared to healthy controls.
|
30639417 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Gastrointestinal peptides such as peptide YY (PYY) can regulate appetite, which is relevant to the study of obesity.
|
28626523 |
2017 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Abnormal plasma ghrelin and PYY levels compared with controls have been reported for subjects with Prader-Willi syndrome (PWS) which is characterized by infantile hypotonia, poor suck reflex and failure to thrive followed by hyperphagia and marked obesity in early childhood.
|
15754036 |
2005 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the human PYY and Y2 receptor genes may contribute to the development of obesity.
|
16756746 |
2006 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Together, these findings suggest that low circulating levels of PYY could contribute to hyperinsulinemia and insulin resistance, and possibly contribute to subsequent development of obesity and type 2 diabetes.
|
17045646 |
2006 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
RESEARCH DESIGN AND METHODS We studied 35 monozygotic (MZ) and 75 dizygotic (DZ) twin pairs (discordant and concordant for obesity) to determine the heritability of glucagon-like peptide 1 (GLP-1) responses to an oral glucose tolerance test (OGTT) and the influence of acquired obesity to GLP-1, glucose-dependent insulinotropic peptide (GIP), and peptide YY (PYY) during OGTT or meal test.
|
23990519 |
2014 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we aimed to assess whether low fasting and postprandial PYY secretion is an early defect, potentially promoting the development of obesity and T2D, and whether it is modified by macronutrient content.
|
18317469 |
2008 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The PYY variants were not associated with obesity, whereas four variants from two haplotype blocks in Y2R were marginally associated (P = 0.054-0.067) with obesity.
|
15855352 |
2005 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, mutations in PYY and Y2R are not commonly found in humans with severe early-onset obesity.
|
15331560 |
2004 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Functional genetic variation at the PYY locus influences multiple heritable metabolic syndrome traits, likely conferring susceptibility to obesity and subsequent cardiorenal disease.
|
19820027 |
2009 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found no association to obesity for the PYY Arg72Thr polymorphism, which is located nearby the essential carboxy terminal.
|
16331299 |
2006 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that modulating the release of endogenous satiety factors, such as PYY, through alteration of specific diet constituents could provide a rational therapy for obesity.
|
16950139 |
2006 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Role of Neuropeptide Y and Peptide YY in the Development of Obesity via Gut-brain Axis.
|
30678628 |
2019 |