PYY, peptide YY, 5697

N. diseases: 88; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0740651
Disease: Abdominal symptom
Abdominal symptom
0.010 Biomarker phenotype BEFREE Diet management involving consuming a low-FODMAP diet restores the density of PYY cells in the large intestine and improves abdominal symptoms in patients with IBS. 31727345 2020
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.010 AlteredExpression disease BEFREE In this prospective case-control study nested within the Mano a Mano Cohort Study, we assessed the risk of breast cancer with regard to plasma levels of c-peptide, gastric inhibitory polypeptide, insulin, leptin, monocyte chemoattractant protein-1, pancreatic polypeptide, and peptide YY. 31292496 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 Biomarker disease BEFREE Changes in plasma levels of cholecystokinin, neurotensin, VIP and PYY in gastric and colorectal cancer - Preliminary results. 31541684 2019
CUI: C0029453
Disease: Osteopenia
Osteopenia
0.010 AlteredExpression disease BEFREE These findings demonstrate that PYY acts as a negative regulator of osteoblastic bone formation, implicating increased PYY levels in the pathogenesis of bone loss during anorexia or following bariatric surgery. 31306808 2019
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.010 Biomarker disease BEFREE The aim of this review is to summarize the current knowledge of the actions of GIP, GLP-1, GLP-2, and PYY on bone metabolism, and to discuss future therapies targeting these receptors for the treatment of osteoporosis. 30863364 2019
CUI: C0338451
Disease: Frontotemporal dementia
Frontotemporal dementia
0.010 GeneticVariation disease BEFREE One hundred and twenty-seven participants (36 ALS, 26 ALS- cognitive, patients with additional cognitive behavioral features, and 35 behavioral variant FTD (bvFTD) and 30 controls) underwent fasting blood analyses of leptin, ghrelin, neuropeptide Y (NPY), peptide YY (PYY), and insulin levels. 30911572 2019
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.010 Biomarker phenotype BEFREE Significant differences were found for all bio/psycho/family markers among obese preadolescents with the exceptions of cortisol, peptide YY and maternal state-anxiety and depression. 31590062 2019
CUI: C0362046
Disease: Prediabetes syndrome
Prediabetes syndrome
0.010 Biomarker disease BEFREE Combined GLP-1, Oxyntomodulin, and Peptide YY Improves Body Weight and Glycemia in Obesity and Prediabetes/Type 2 Diabetes: A Randomized, Single-Blinded, Placebo-Controlled Study. 31177183 2019
CUI: C0426576
Disease: Gastrointestinal symptom
Gastrointestinal symptom
0.010 AlteredExpression phenotype BEFREE Gastrointestinal symptoms and circulating levels of peptide YY (PYY) were also measured. 30413932 2019
CUI: C0548823
Disease: Distress gastrointestinal
Distress gastrointestinal
0.010 Biomarker phenotype BEFREE In studies of biological correlates, women with purging disorder demonstrated significantly greater postprandial increases in the satiety peptide, peptide tyrosine tyrosine, compared to women with bulimia nervosa and controls, and these differences predicted greater gastrointestinal distress in purging disorder. 31306252 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.010 AlteredExpression disease BEFREE In this prospective case-control study nested within the Mano a Mano Cohort Study, we assessed the risk of breast cancer with regard to plasma levels of c-peptide, gastric inhibitory polypeptide, insulin, leptin, monocyte chemoattractant protein-1, pancreatic polypeptide, and peptide YY. 31292496 2019
Malignant neoplasm of colon and/or rectum
0.010 Biomarker disease BEFREE Changes in plasma levels of cholecystokinin, neurotensin, VIP and PYY in gastric and colorectal cancer - Preliminary results. 31541684 2019
CUI: C0003467
Disease: Anxiety
Anxiety
0.010 Biomarker disease BEFREE Compared with HCs, in patients with AN at Wk0, baseline ghrelin, PYY, fullness, bloating and anxiety were higher, and hunger less, and in response to the meal, ghrelin, bloating and anxiety were greater, and hunger less (all <i>p</i> < 0.05). 30597915 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.010 Biomarker group BEFREE Compared with HCs, in patients with AN at Wk0, baseline ghrelin, PYY, fullness, bloating and anxiety were higher, and hunger less, and in response to the meal, ghrelin, bloating and anxiety were greater, and hunger less (all <i>p</i> < 0.05). 30597915 2018
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia
0.010 AlteredExpression phenotype BEFREE After wholemeal pasta, glucose, triglyceride increased and GLP-1 responses were not different compared to control pasta but insulin response at 30 min (p<0.05) and ghrelin at 60 min (p=0.03) were lower and PYY levels higher (AUC=+44%, p=0.001). 29427691 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.010 Biomarker disease BEFREE Serum concentration of clozapine and fasting serum levels of des-acylated ghrelin, neuropeptide Y (NPY), agouti-related protein (AgRP), peptide YY (PYY(1-36)), cocaine- and amphetamine-regulated transcript (CART), leptin and obestatin were measured in 30 subjects with schizophrenia on clozapine monotherapy. 29275180 2018
CUI: C0265344
Disease: Donohue Syndrome
Donohue Syndrome
0.010 Biomarker disease BEFREE Two siblings with genetically confirmed DS and extremely low weight underwent a mixed meal (MM) test where pancreatic hormones insulin, C-peptide, glucagon, active amylin, pancreatic polypeptide (PP) as well as gut hormones active glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), ghrelin, peptide YY (PYY) and leptin were analyzed using a Multiplex assay. 29226618 2018
CUI: C0700613
Disease: Anxiety state
Anxiety state
0.010 Biomarker disease BEFREE Appetite Perceptions, Gastrointestinal Symptoms, Ghrelin, Peptide YY and State Anxiety Are Disturbed in Adolescent Females with Anorexia Nervosa and Only Partially Restored with Short-Term Refeeding. 30597915 2018
CUI: C1279420
Disease: Anxiety neurosis (finding)
Anxiety neurosis (finding)
0.010 Biomarker disease BEFREE Appetite Perceptions, Gastrointestinal Symptoms, Ghrelin, Peptide YY and State Anxiety Are Disturbed in Adolescent Females with Anorexia Nervosa and Only Partially Restored with Short-Term Refeeding. 30597915 2018
CUI: C0021831
Disease: Intestinal Diseases
Intestinal Diseases
0.010 Biomarker group BEFREE Altered levels of colonic peptide YY (PYY) have been reported in patients suffering from functional and inflammatory bowel disorders. 28106168 2017
CUI: C0027497
Disease: Nausea
Nausea
0.010 AlteredExpression phenotype BEFREE GES reduces NUCB2/nesfatin-1 levels under fasting conditions and postprandial PYY levels in patients suffering from nausea and/or vomiting refractory to pharmacological therapies. 28795473 2017
CUI: C0030193
Disease: Pain
Pain
0.010 Biomarker phenotype BEFREE These results indicate that endogenous PYY has a hypoalgesic effect on somatic thermal and visceral chemical pain. 28106168 2017
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
0.010 AlteredExpression disease BEFREE The plasma levels of serotonin, ghrelin, and peptide YY (PYY) were significantly decreased in patients with PCOS compared with controls, and have a significantly negative correlation with waist circumference and testosterone. 28293234 2017
CUI: C0234245
Disease: Visceral Pain
Visceral Pain
0.010 Biomarker phenotype BEFREE While the involvement of neuropeptide Y (NPY) and Y receptors in the regulation of nociception is well established, the physiological role of PYY in somatic and visceral pain is poorly understood. 28106168 2017
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
0.010 Biomarker disease BEFREE In this study we examined plasma concentrations of glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide 1 (GLP-1), pancreatic polypeptide (PP), peptide YY (PYY) and neuropeptide Y (NPY), and cytokines leptin and adiponectin in 94 patients with histologically confirmed PDAC. 28027898 2017