Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
p21<sup>cip1/waf1</sup> mediates various biological activities by sensing and responding to multiple stimuli, via p53-dependent and independent pathways. p21 is known to act as a tumor suppressor mainly by inhibiting cell cycle progression and allowing DNA repair.
|
31575057 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
p16<sup>Ink4a</sup> and p21<sup>Cip1/Waf1</sup> promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis.
|
29234059 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Greater protein expression was detected for FGFR3, PI3Kp110α, PI3KClassIII, cyclins D1 and D3 and p21Waf1/Cip1 in the tumour tissue than in the healthy mucosa.
|
27726892 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
DEK significantly upregulated the expression levels of pro-apoptotic proteins such as cleaved caspase-3, cleaved caspase-9, cleaved PARP, p53, Bax, and tumor suppressor p21<sup>Cip1/Waf1</sup>, downregulated the levels of cell cycle regulating proteins such as cyclinD1, CDK2, and CDK4 and carcinogenic proteins such as EGFR and COX-2, and suppressed the activation of Akt.
|
28169543 |
2017 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Although known to induce cellular senescence, an important tumour suppressor mechanism, mutation of CDKN1A - the gene encoding p21 (also known as WAF1 or CIP1) - is rare in human cancers.
|
27350444 |
2016 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Through gain- and loss-of-function experiments, we demonstrated that the DRAK1 expression level regulated TGF-β1-induced transcriptional activity and expression of the tumor suppressor gene p21(Waf1/Cip1).
|
25531329 |
2015 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In cells expressing high levels of tumor suppressor p21WAF1/Cip1, it represses E2F1-mediated transcription, leading to down-regulation of multiple E2F1 target genes encoding for S-phase specific proteins, epigenetic modulators, and miRNAs (e.g. miR-15/16), and thereby stalling progression through the S-phase of cell cycle.
|
25738367 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.).
|
23318451 |
2014 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This new and unprecedented evidence for a link between SdhD dysfunction and p21(WAF1/Cip1) will open new avenues for the study of the mechanisms that cause tumors in Sdh mutants.
|
24465590 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry (IHC) revealed decreased levels of Cul4A-associated proteins p21(CIP1) and tumour suppressor p19(ARF) in the lung tumours, suggesting that Cul4A regulated their expression in these tumours.
|
24648314 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
AMPK is a key effector of the tumor suppressor liver kinase B 1 (LKB1) which inhibits the cellular growth mediator mammalian target of rapamycin (mTOR) and activates checkpoint mediators such as p53 and the cyclin dependent kinase inhibitors p21(cip1) and p27(kip1).
|
24100703 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These bioactive components have the ability to block UV-induced DNA hypermethylation and histone modifications in the skin required for the silencing of tumor suppressor genes (e.g.Cip1/p21, p16(INK4a) ).
|
22017262 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Further, GSP treatment resulted in re-expression of the mRNA and proteins of silenced tumor suppressor genes, RASSF1A, p16(INK4a) and Cip1/p21.
|
22749965 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, these results suggest that the p21(cip1) - and p27(kip1) -associated signaling pathways might be involved in the TB-induced anti-proliferation in KB cells.In vivo, TB (50 mg/kg, i.p.) significantly inhibited the KB tumor size.
|
21563217 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Yin Yang-1 inhibits tumor cell growth and inhibits p21WAF1/Cip1 complex formation with cdk4 and cyclin D1.
|
22322893 |
2012 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Dietary administration of GSPs (0.5%, w/w) in supplementation with AIN76A control diet inhibited the growth of SCC1 tumor xenografts in athymic nude mice, which was associated with: (i) inhibition of cell proliferation, (ii) induction of apoptosis of tumor xenograft cells, (iii) decreased expression of cyclins and Cdks, (iv) decreased expression of EGFR, and (v) increased expression of Cip1/p21 and Kip1/p27 proteins and their increased binding to Cdks in tumor xenograft samples.
|
23050025 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study demonstrates that KLF10 is a tumor suppressor and that it targets p21(WAF1/CIP1) transcription.
|
22349513 |
2012 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21(Cip1) expression and hampers tumour cell growth in vitro and in vivo.
|
22117196 |
2012 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Both of p21(WAF1/Cip1)and TGF-β1's expression correlated with tumor differentiations. miR-221's upregulation and p27(Kip1)'s downregulation were significantly associated with tumor stages and metastasis.
|
20146005 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This phenomenon is associated with a reduction in CDKs 4/2 (cyclin-dependent kinases) and cyclins E and D1 expression and an accumulation of p21(Waf1/Cip1) (a cyclin-dependent kinase inhibitor) and p53 (a tumor-suppressing protein).
|
20683915 |
2011 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thus, our results suggest that KLF4 may function as a tumor suppressor in the skin and that the deregulated expression of KLF4 in the context of p21(Waf1/Cip1) and cyclin D1 expression may be involved in skin tumorigenesis.
|
21132436 |
2011 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found that depletion of SPARC induces G2/M cell cycle arrest and tumor growth inhibition with activation of p53 and induction of p21(Cip1/Waf1) acting as a checkpoint, preventing efficient mitotic progression.
|
20955243 |
2011 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Re-expression of GATA4 in human GBM cell lines, primary cultures, and brain tumor-initiating cells suppressed tumor growth in vitro and in vivo through direct activation of the cell cycle inhibitor P21(CIP1), independent of TP53.
|
21464220 |
2011 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
No correlations regarding protein expression and clinicopathological characteristics were observed; down-regulation of expression of P21(CIP1) with low (I-II) tumor stage (p=0.0777), and older age (>50 years old) with negative or mislocalization of P27(KIP1) (p=0.0922) were of borderline the statistical significance.
|
20668328 |
2010 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cyclin-dependent kinase inhibitor protein p21(Waf1/Cip1) is a potent tumor suppressor.
|
20301197 |
2010 |