|
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> Compared to controls, SZ subjects had nonsignificant trends toward a decrease in vGLUT1, and an increase in both vGLUT2 and GAD67. vGLUT1 was negatively correlated with GAD67 in normal controls (NCs) and positively correlated in SZ subjects.
|
31062628 |
2019 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study used western blot analysis to compare protein levels of tyrosine hydroxylase (TH), glutamate decarboxylase (GAD67), and vesicular glutamate transporters (vGLUT1 and vGLUT2) in postmortem human SN in schizophrenia subjects (n=13) and matched controls (n=12).
|
27550734 |
2017 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
To test this hypothesis, we examined protein expression of excitatory amino acid transporter 1-3 and vesicular glutamate transporter 1 and 2 in subjects with schizophrenia (n=23) and a comparison group (n=27).
|
23356950 |
2013 |
|
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To test this hypothesis, we examined protein expression of excitatory amino acid transporter 1-3 and vesicular glutamate transporter 1 and 2 in subjects with schizophrenia (n=23) and a comparison group (n=27).
|
23356950 |
2013 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Our data may be important for a better understanding of the contribution of reduced VGLUT1-mediated presynaptic glutamatergic neurotransmission in the generation of several behavioural abnormalities associated with schizophrenia.
|
22197296 |
2012 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We examined the ratio of excitatory to inhibitory vesicular neurotransmitter transporter mRNAs (VGluT1 to VGAT) and their ratio in the dorsolateral prefrontal cortex during normal human development and in people with schizophrenia and controls by quantitative RT-PCR.
|
21396926 |
2011 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We determined if mRNAs encoding presynaptic proteins enriched in inhibitory (vesicular gamma-aminobutyric acid transporter [VGAT] and complexin 1) and/or excitatory (vesicular glutamate transporter 1 [VGluT1] and complexin 2) terminals are altered in the dorsolateral prefrontal cortex of subjects with schizophrenia (n = 37 patients, n = 37 control subjects).
|
21145444 |
2011 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
No significant changes in complexin 1, VGAT, complexin 2, VGluT1, dysbindin, NAV2, or VAMP1 mRNA expression were found; however, expression of mRNAs associated with plasticity/cytoskeletal modification (GAP43 and NAV1) was reduced in schizophrenia.
|
21145444 |
2011 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The VGluT1 mRNA/VGAT mRNA ratio was unchanged in schizophrenia, as was the ratio of complexin 2 mRNA to complexin 1 mRNA (related to synaptic vesicle fusion in excitatory and inhibitory terminals, respectively).
|
21396926 |
2011 |
|
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found decreased VGLUT1 mRNA expression in both MDD and BD in the entorhinal cortex (ERC), decreased VGLUT2 mRNA expression in MDD in the middle temporal gyrus, and increased VGLUT2 mRNA expression in SCZ in the inferior temporal gyrus (ITG).
|
19839996 |
2009 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, the density of vGluT1-immunoreactive boutons was significantly decreased by 79% in layer 3, but was unchanged in layer 5 of the PFC in schizophrenia.
|
19917116 |
2009 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to investigate the involvement of the human VGLUT1 in the susceptibility to schizophrenia.
|
19720501 |
2009 |
|
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found increased VGLUT1 transcript and reduced VGLUT1 protein expression in the ACC, but not DLPFC, in schizophrenia.
|
18155679 |
2008 |
|
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
We found increased VGLUT1 transcript and reduced VGLUT1 protein expression in the ACC, but not DLPFC, in schizophrenia.
|
18155679 |
2008 |
|
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Hippocampal VGLUT1 mRNA declined with age selectively in the schizophrenia group.
|
15653259 |
2005 |
|
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hippocampal VGLUT1 mRNA declined with age selectively in the schizophrenia group.
|
15653259 |
2005 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
An inversely correlated increase in vesicular glutamate transporter-1 (VGluT-1) occurred in DGiml of the same schizophrenia cases.
|
15124027 |
2004 |
|
Memory impairment
|
0.310 |
GeneticVariation
|
phenotype |
BEFREE |
After the onset of memory deficits in 3xTg-AD mice, a three weeks treatment with the selective A<sub>2A</sub>R antagonist normalized the up-regulation of hippocampal A<sub>2A</sub>R and restored hippocampal-dependent reference memory, as well as the decrease of hippocampal synaptic plasticity (60.0 ± 3.7% decrease of long-term potentiation amplitude) and the decrease of global (syntaxin-I) and glutamatergic synaptic markers (vGluT1).
|
29859867 |
2018 |
|
Anhedonia
|
0.310 |
Biomarker
|
disease |
BEFREE |
SIRT2 inhibition reverses anhedonia in the VGLUT1+/- depression model.
|
28778545 |
2017 |
|
Anhedonia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Chronic social defeat stress model: behavioral features, antidepressant action, and interaction with biological risk factors.
|
22707231 |
2012 |
|
Memory impairment
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
Expression of VGLUTs contributes to degeneration and acquisition of learning and memory.
|
21295146 |
2011 |
|
Bipolar Disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Increased VGluT1 expression is supportive of elevated glutamate neurotransmission in the anterior cingulate cortex in bipolar disorder.
|
20079890 |
2010 |
|
Bipolar Disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
We also found a negative correlation between age and VGLUT1 mRNA expression in BD in the ERC and ITG.
|
19839996 |
2009 |
|
Bipolar Disorder
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We also found a negative correlation between age and VGLUT1 mRNA expression in BD in the ERC and ITG.
|
19839996 |
2009 |
|
Anhedonia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1.
|
19409534 |
2009 |