Rett Syndrome
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The gene for the human CREB binding protein, the transcriptional coactivator CBP, is included in the RT1 cosmid, and mutations in CBP have recently been identified in nondeleted RTS patients.
|
9677064 |
1998 |
Rubinstein-Taybi Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism.
|
9949198 |
1999 |
Acute leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results provide further evidence for the multiple contribution of both MOZ and CBP genes in acute leukemias.
|
10469454 |
1999 |
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
RT-PCR analysis of the MOZ-CBP and CBP-MOZ chimeric transcripts in acute myeloid leukemias with t(8;16)(p11;p13).
|
10862050 |
2000 |
Leukemia, Myelocytic, Acute
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
An MLL gene rearrangement and MLL-CBP chimeric mRNA were found in AML, but not in ALL.
|
10679915 |
2000 |
Rothmund-Thomson syndrome
|
0.080 |
Biomarker
|
disease |
BEFREE |
Here we report diagnostic analysis of CBP in 194 RTS patients, divided into several subsets.
|
10699051 |
2000 |
Rett Syndrome
|
0.080 |
Biomarker
|
disease |
BEFREE |
Here we report diagnostic analysis of CBP in 194 RTS patients, divided into several subsets.
|
10699051 |
2000 |
Leukemogenesis
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
The transcriptional coactivators, CBP and p300, were found to be involved in leukemogenesis through translocations.
|
11071359 |
2000 |
Leukemogenesis
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
In the only t(8;16) that has been described at the sequence level using RT-PCR, the CBP-MOZ fusion was found to be out-of-frame, suggesting that the reciprocal MOZ-CBP transcript is the essential one for leukemogenesis.
|
10862050 |
2000 |
Treatment related acute myeloid leukaemia
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
MLL-CBP fusion transcript in a therapy-related acute myeloid leukemia with the t(11;16)(q23;p13) which developed in an acute lymphoblastic leukemia patient with Fanconi anemia.
|
10679915 |
2000 |
Acute lymphocytic leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A diagnosis of FA was confirmed by an increased number of chromosomal breaks and rearrangements in peripheral blood lymphocytes cultured with mitogen in the presence of mitomycin C. We conclude that this FA patient developed ALL followed by a therapy-related t(11;16)-AML resulting in an MLL-CBP fusion.
|
10679915 |
2000 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
MLL-CBP fusion transcript in a therapy-related acute myeloid leukemia with the t(11;16)(q23;p13) which developed in an acute lymphoblastic leukemia patient with Fanconi anemia.
|
10679915 |
2000 |
Childhood Acute Lymphoblastic Leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A diagnosis of FA was confirmed by an increased number of chromosomal breaks and rearrangements in peripheral blood lymphocytes cultured with mitogen in the presence of mitomycin C. We conclude that this FA patient developed ALL followed by a therapy-related t(11;16)-AML resulting in an MLL-CBP fusion.
|
10679915 |
2000 |
Acute leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The MLL gene is fused with the cAMP-responsive element binding protein-binding protein (CBP) gene in t(11;16)(q23;p13), which has been reported to be associated with therapy-related acute leukemia.
|
10706136 |
2000 |
Adult Acute Lymphocytic Leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A diagnosis of FA was confirmed by an increased number of chromosomal breaks and rearrangements in peripheral blood lymphocytes cultured with mitogen in the presence of mitomycin C. We conclude that this FA patient developed ALL followed by a therapy-related t(11;16)-AML resulting in an MLL-CBP fusion.
|
10679915 |
2000 |
Noninfiltrating Intraductal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of ER-alpha, TIF2, and CBP were significantly higher in the intraductal carcinomas than those in the normal mammary glands.
|
10690532 |
2000 |
Fanconi Anemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A diagnosis of FA was confirmed by an increased number of chromosomal breaks and rearrangements in peripheral blood lymphocytes cultured with mitogen in the presence of mitomycin C. We conclude that this FA patient developed ALL followed by a therapy-related t(11;16)-AML resulting in an MLL-CBP fusion.
|
10679915 |
2000 |
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immortalization of T lymphocytes by human T-cell leukemia virus type 1 is independent of the tax-CBP/p300 interaction.
|
11090202 |
2000 |
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A diagnosis of FA was confirmed by an increased number of chromosomal breaks and rearrangements in peripheral blood lymphocytes cultured with mitogen in the presence of mitomycin C. We conclude that this FA patient developed ALL followed by a therapy-related t(11;16)-AML resulting in an MLL-CBP fusion.
|
10679915 |
2000 |
Acute monocytic/monoblastic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We have developed an RT-PCR strategy that enables us to detect the MOZ-CBP as well as the CBP-MOZ fusions in the two AML M5 with t(8;16)(p11;p13) analyzed.
|
10862050 |
2000 |
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13).
|
11157802 |
2001 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, these findings suggest that one of the mechanisms by which EWS-ATF-1 may cause tumors is through targeting CBP/p300 resulting in the loss of function of p53.
|
11709699 |
2001 |
Rubinstein-Taybi Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
CBP is the causative gene of Rubinstein-Taybi syndrome (RTS).
|
11331617 |
2001 |
Rothmund-Thomson syndrome
|
0.080 |
Biomarker
|
disease |
BEFREE |
CBP is the causative gene of Rubinstein-Taybi syndrome (RTS).
|
11331617 |
2001 |
Rett Syndrome
|
0.080 |
Biomarker
|
disease |
BEFREE |
CBP is the causative gene of Rubinstein-Taybi syndrome (RTS).
|
11331617 |
2001 |