|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the association between genetic polymorphisms in CYSLTR2 with asthma phenotypes, atopy markers and helminth infection.
|
31126515 |
2019 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
On the other hand, although degrees of CysLT2 receptors expression were variable among the 5 non-asthma subjects, the expression in the asthma lung was detected on bronchial smooth muscle, epithelium and alveolar leukocytes in 2 in 2 asthma subjects.
|
26433531 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Peripheral and central airway fibroblasts, from asthmatics and healthy controls, were investigated for the amount of cysteinyl-leukotriene receptors (CysLT(1) and CysLT(2)), leukotriene B(4) receptors (BLT(1) and BLT(2)), IL-13 receptor-α(1) (IL-13Rα(1)) and the IL-4 receptor (IL-4R).
|
21596548 |
2011 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PMA/ionomycin induced higher mRNA expression of CysLTR2 in B cell lines from ht2+/+ asthmatics than those from ht1+/+ asthmatics.
|
19840403 |
2009 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Those specific variants include 2 variants in the 5-lipoxygenase gene (ALOX5) that are both associated with response to 5-lipoxygenase inhibition and to leukotriene receptor antagonists, variants in genes encoding the 2 established cysteinyl leukotriene receptor antagonists (CYSLTR1 and CYSLTR2) that are both associated with asthma susceptibility in at least 2 independent populations, and a leukotriene C(4) synthase promoter polymorphism (LTC4s) that has been associated with asthma affection status and asthma-exacerbated respiratory disease.
|
19665766 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
CYSLTR2 and ALOX5 polymorphisms may predispose a minority of individuals to excessive cysteinyl-leukotriene concentrations, yielding a distinct asthma phenotype most likely to respond to leukotriene modifier pharmacotherapy.
|
17460547 |
2007 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GPCR genes implicated in asthma endophenotypes include variants of the cysteinyl leukotriene receptors (CYSLTR1 and CYSLTR2), and prostaglandin D2 receptors (PTGDR and CRTH2), thromboxane A2 receptor (TBXA2R), beta2-adrenergic receptor (ADRB2), chemokine receptor 5 (CCR5), and the G protein-coupled receptor associated with asthma (GPRA).
|
17154652 |
2006 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In an effort to discover additional polymorphism(s), the variant(s) of which have been implicated in asthma and aspirin intolerance, we scrutinized genetic polymorphisms of the CYSLTR2 gene, and evaluated this locus as a potential candidate for asthma.
|
15970796 |
2005 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that CYSLTR2 is one of the genes that contributes to susceptibility to asthma in the Japanese population.
|
15454733 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association of CYSLTR2 polymorphisms with asthma was assessed by transmission disequilibrium test in two family-based collections (359 families from Denmark and Minnesota, USA and 384 families from the Genetics of Asthma International Network).
|
15475736 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Our results suggest that CYSLTR2 is one of the genes that contributes to susceptibility to asthma in the Japanese population.
|
15454733 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The novel M201V [corrected] CysLT2 receptor variant was associated with atopy (21%) on Tristan da Cunha compared with those who were non-atopic (7%) (Fisher's exact test, P=0.0016) in a manner that was independent of asthma (two-way ANOVA, P=0.0015).
|
14515063 |
2003 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cysteinyl leukotrienes (CysLTs) have been implicated as important contributors in the pathophysiology of asthma and their biological effects are mediated by at least two distinct G-protein-coupled receptors. cDNA sequences of cysteinyl leukotriene receptor 1 (CysLTR1) and cysteinyl leukotriene receptor 2 (CysLTR2) have recently been elucidated.
|
11696047 |
2001 |