CYSLTR2, cysteinyl leukotriene receptor 2, 57105

N. diseases: 60; N. variants: 4
Disease: Uveal melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0220633
Disease: Uveal melanoma
Uveal melanoma 		0.530 GeneticVariation disease BEFREE These data indicate that mutations in the PLCB4 and CYSLTR2 genes are rare in Chinese UM patients. 31614358 2019
CUI: C0220633
Disease: Uveal melanoma
Uveal melanoma 		0.530 GeneticVariation disease BEFREE Uveal melanoma (UM), a rare cancer of the eye, is characterized by initiating mutations in the genes G-protein subunit alpha Q (<i>GNAQ</i>), G-protein subunit alpha 11 (<i>GNA11</i>), cysteinyl leukotriene receptor 2 (<i>CYSLTR2</i>), and phospholipase C beta 4 (<i>PLCB4</i>) and by metastasis-promoting mutations in the genes splicing factor 3B1 (<i>SF3B1</i>), serine and arginine rich splicing factor 2 (SRSF2), and BRCA1-associated protein 1 (<i>BAP1</i>). 31671564 2019
CUI: C0220633
Disease: Uveal melanoma
Uveal melanoma 		0.530 Biomarker disease CTD_human Our findings implicate CYSLTR2 as a uveal melanoma oncogene and highlight the critical role of Gαq signaling in uveal melanoma pathogenesis. 27089179 2016
CUI: C0220633
Disease: Uveal melanoma
Uveal melanoma 		0.530 SomaticCausalMutation disease ORPHANET Our findings implicate CYSLTR2 as a uveal melanoma oncogene and highlight the critical role of Gαq signaling in uveal melanoma pathogenesis. 27089179 2016
CUI: C0220633
Disease: Uveal melanoma
Uveal melanoma 		0.530 Biomarker disease BEFREE Our findings implicate CYSLTR2 as a uveal melanoma oncogene and highlight the critical role of Gαq signaling in uveal melanoma pathogenesis. 27089179 2016