|
Uveal melanoma
|
0.530 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that mutations in the PLCB4 and CYSLTR2 genes are rare in Chinese UM patients.
|
31614358 |
2019 |
|
Uveal melanoma
|
0.530 |
GeneticVariation
|
disease |
BEFREE |
Uveal melanoma (UM), a rare cancer of the eye, is characterized by initiating mutations in the genes G-protein subunit alpha Q (<i>GNAQ</i>), G-protein subunit alpha 11 (<i>GNA11</i>), cysteinyl leukotriene receptor 2 (<i>CYSLTR2</i>), and phospholipase C beta 4 (<i>PLCB4</i>) and by metastasis-promoting mutations in the genes splicing factor 3B1 (<i>SF3B1</i>), serine and arginine rich splicing factor 2 (SRSF2), and BRCA1-associated protein 1 (<i>BAP1</i>).
|
31671564 |
2019 |
|
Uveal melanoma
|
0.530 |
Biomarker
|
disease |
CTD_human |
Our findings implicate CYSLTR2 as a uveal melanoma oncogene and highlight the critical role of Gαq signaling in uveal melanoma pathogenesis.
|
27089179 |
2016 |
|
Uveal melanoma
|
0.530 |
SomaticCausalMutation
|
disease |
ORPHANET |
Our findings implicate CYSLTR2 as a uveal melanoma oncogene and highlight the critical role of Gαq signaling in uveal melanoma pathogenesis.
|
27089179 |
2016 |
|
Uveal melanoma
|
0.530 |
Biomarker
|
disease |
BEFREE |
Our findings implicate CYSLTR2 as a uveal melanoma oncogene and highlight the critical role of Gαq signaling in uveal melanoma pathogenesis.
|
27089179 |
2016 |
|
Malignant melanoma of iris
|
0.400 |
SomaticCausalMutation
|
disease |
ORPHANET |
Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma.
|
27089179 |
2016 |
|
Malignant melanoma of choroid
|
0.400 |
SomaticCausalMutation
|
disease |
ORPHANET |
Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma.
|
27089179 |
2016 |
|
Malignant melanoma of iris
|
0.400 |
Biomarker
|
disease |
HPO |
|
|
|
|
Malignant melanoma of choroid
|
0.400 |
Biomarker
|
disease |
HPO |
|
|
|
|
Asthma, Aspirin-Induced
|
0.310 |
Biomarker
|
disease |
CTD_human |
Genetic and ethnic risk factors associated with drug hypersensitivity.
|
20485159 |
2010 |
|
Asthma, Aspirin-Induced
|
0.310 |
Biomarker
|
disease |
CTD_human |
Increased expression of CYSLTR1 with CYLSTR1 and CYSLTR2 polymorphisms are new findings in AIA, while the ALOX5 promoter polymorphism has been noted in AIU.
|
16502481 |
2006 |
|
Asthma, Aspirin-Induced
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Increased expression of CYSLTR1 with CYLSTR1 and CYSLTR2 polymorphisms are new findings in AIA, while the ALOX5 promoter polymorphism has been noted in AIU.
|
16502481 |
2006 |
|
Drug Allergy
|
0.300 |
Biomarker
|
group |
CTD_human |
Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics.
|
15970796 |
2005 |
|
Pulmonary Fibrosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice.
|
15328359 |
2004 |
|
Alveolitis, Fibrosing
|
0.300 |
Biomarker
|
disease |
CTD_human |
Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice.
|
15328359 |
2004 |
|
Reperfusion Injury
|
0.200 |
Biomarker
|
disease |
RGD |
Cysteinyl leukotriene receptor 2 is spatiotemporally involved in neuron injury, astrocytosis and microgliosis after focal cerebral ischemia in rats.
|
21664436 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the association between genetic polymorphisms in CYSLTR2 with asthma phenotypes, atopy markers and helminth infection.
|
31126515 |
2019 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
On the other hand, although degrees of CysLT2 receptors expression were variable among the 5 non-asthma subjects, the expression in the asthma lung was detected on bronchial smooth muscle, epithelium and alveolar leukocytes in 2 in 2 asthma subjects.
|
26433531 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Peripheral and central airway fibroblasts, from asthmatics and healthy controls, were investigated for the amount of cysteinyl-leukotriene receptors (CysLT(1) and CysLT(2)), leukotriene B(4) receptors (BLT(1) and BLT(2)), IL-13 receptor-α(1) (IL-13Rα(1)) and the IL-4 receptor (IL-4R).
|
21596548 |
2011 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PMA/ionomycin induced higher mRNA expression of CysLTR2 in B cell lines from ht2+/+ asthmatics than those from ht1+/+ asthmatics.
|
19840403 |
2009 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Those specific variants include 2 variants in the 5-lipoxygenase gene (ALOX5) that are both associated with response to 5-lipoxygenase inhibition and to leukotriene receptor antagonists, variants in genes encoding the 2 established cysteinyl leukotriene receptor antagonists (CYSLTR1 and CYSLTR2) that are both associated with asthma susceptibility in at least 2 independent populations, and a leukotriene C(4) synthase promoter polymorphism (LTC4s) that has been associated with asthma affection status and asthma-exacerbated respiratory disease.
|
19665766 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
CYSLTR2 and ALOX5 polymorphisms may predispose a minority of individuals to excessive cysteinyl-leukotriene concentrations, yielding a distinct asthma phenotype most likely to respond to leukotriene modifier pharmacotherapy.
|
17460547 |
2007 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GPCR genes implicated in asthma endophenotypes include variants of the cysteinyl leukotriene receptors (CYSLTR1 and CYSLTR2), and prostaglandin D2 receptors (PTGDR and CRTH2), thromboxane A2 receptor (TBXA2R), beta2-adrenergic receptor (ADRB2), chemokine receptor 5 (CCR5), and the G protein-coupled receptor associated with asthma (GPRA).
|
17154652 |
2006 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In an effort to discover additional polymorphism(s), the variant(s) of which have been implicated in asthma and aspirin intolerance, we scrutinized genetic polymorphisms of the CYSLTR2 gene, and evaluated this locus as a potential candidate for asthma.
|
15970796 |
2005 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that CYSLTR2 is one of the genes that contributes to susceptibility to asthma in the Japanese population.
|
15454733 |
2004 |