RTN4, reticulon 4, 57142

N. diseases: 71; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits. 30040841 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE The TATC and CAA insertion/deletion polymorphisms of RTN4 3'-UTR have been linked to schizophrenia, depression, and dilated cardiomyopathy. 22320844 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE Allelic tests showed nominally significant association of two RTN4 SNPs (P = 0.047 and 0.037 for rs11894868 and rs2968804, respectively) and two MAG SNPs (P = 0.034 and 0.029 for rs7249617 and rs16970218, respectively) with schizophrenia. 21563301 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease CTD_human Constitutive genetic deletion of the growth regulator Nogo-A induces schizophrenia-related endophenotypes. 20071518 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 AlteredExpression disease LHGDN Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. 19165527 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE The TATC and CAA 3'UTR insertion/deletion polymorphisms of the RTN4, the gene encoding Nogo isoforms A, B and C, have been linked to schizophrenia and depression, but data were inconsistent. 18948092 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 AlteredExpression disease LHGDN Nogo A, B and C expression in schizophrenia, depression and bipolar frontal cortex, and correlation of Nogo expression with CAA/TATC polymorphism in 3'-UTR. 17022955 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia. 15661375 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease BEFREE The Nogo gene maps to 2p14-p13, a region consistently associated with schizophrenia and bipolar disorder. 15820318 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE Novak et al.[Brain Res.Mol.Brain Res.107 (2002) 183] reported that a CAA insertion in the 3'-untranslated region of the Nogo gene was associated with schizophrenia. 14741411 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE Our current data suggest that the genetic polymorphisms within RTN4 are unlikely to confer an increased susceptibility to schizophrenia in the Chinese population. 15234466 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 AlteredExpression disease LHGDN Because the 3'-untranslated regions of eukaryotic genes are known to regulate gene expression, the increased frequency of the Nogo CAA insert in schizophrenia may contribute to abnormal regulation of Nogo gene expression, and may indicate a role for Nogo in disturbed neurodevelopment in schizophrenia. 12425946 2002
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 AlteredExpression disease BEFREE Because the 3'-untranslated regions of eukaryotic genes are known to regulate gene expression, the increased frequency of the Nogo CAA insert in schizophrenia may contribute to abnormal regulation of Nogo gene expression, and may indicate a role for Nogo in disturbed neurodevelopment in schizophrenia. 12425946 2002
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.330 Biomarker disease BEFREE While little is known about the role of RTN4 in colorectal cancer, this protein has been established as a critical mediator of endoplasmic reticulum tubular network formation. 28352901 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.330 Biomarker disease BEFREE These results indicate that RTN4-C has an important role in colorectal cancer cell growth, which may provide a potential therapeutic approach for human colorectal cancer. 25847052 2015
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.330 Biomarker disease BEFREE International comparisons show strong inverse protective associations with starch, NSP (fibre, non-starch polysaccharides) and vegetable intakes, and positive associations with meat consumption in large bowel cancer. 9103247 1997
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.330 GeneticVariation disease UNIPROT
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 Biomarker disease BEFREE The Nogo gene maps to 2p14-p13, a region consistently associated with schizophrenia and bipolar disorder. 15820318 2005
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0270824
Disease: Visual seizure
Visual seizure 		0.200 Biomarker disease RGD Hippocampal Nogo-A and neo-Timm's staining in amygdala kindling rats. 17439704 2007
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.110 GeneticVariation disease GWASCAT Impact of IFNL4 Genetic Variants on Sustained Virologic Response and Viremia in Hepatitis C Virus Genotype 3 Patients. 31260374 2019
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.110 Biomarker disease BEFREE The Australian NSP Survey (ANSPS), conducted annually at ∼50 NSP services across Australia, consists of a brief self-administered questionnaire and provision of a capillary dried blood spot for HIV and hepatitis C antibody testing. 28104570 2017
CUI: C0427460
Disease: Red cell distribution width determination
Red cell distribution width determination 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C1261502
Disease: Finding of Mean Corpuscular Hemoglobin
Finding of Mean Corpuscular Hemoglobin 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C1304746
Disease: RDW - Red blood cell distribution width result
RDW - Red blood cell distribution width result 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019