|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the function of SALL4 in cervical cancer remains unknown.
|
31336010 |
2019 |
|
Developmental Disabilities
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Notably, previous studies demonstrated the genetic involvement of SALL4 loss-of-function variants in Okihiro syndrome and related syndromic developmental disorders.
|
30603774 |
2019 |
|
Myeloid Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Expression pattern and prognostic implication of SALL4 gene in myeloid leukemias: a case-control study.
|
30638095 |
2019 |
|
Myeloid Leukemia, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among CML patients, the highest percentage of patients with a high SALL4 (p = .033) was among CML-CP.
|
30638095 |
2019 |
|
Liver neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Inhibitors of oxidative phosphorylation might be used for the treatment of liver tumors with high levels of SALL4.
|
31446059 |
2019 |
|
Carcinoma, Neuroendocrine
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical staining for CK20, FLI-1, SATB2, neurofilament, and SALL4 was performed in 6 additional primary ovarian high-grade NECs; One, 5, 5, 1, and 0 cases were positive for CK20, FLI-1, SATB2, neurofilament, and SALL4, respectively, usually with very focal immunoreactivity.
|
31584482 |
2019 |
|
Metastatic melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
3, 3-diaminobenzidine (DAB) immunohistochemical (IHC) staining of ten samples of MM to the brain demonstrated the expression of the embryonic stem cell (ESC) markers OCT4, NANOG, SALL4, SOX2 and pSTAT3.
|
30626524 |
2019 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the function of SALL4 in cervical cancer remains unknown.
|
31336010 |
2019 |
|
High-Grade Squamous Intraepithelial Lesions
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Here, we showed that the expression of SALL4 was gradually increased from normal cervical tissue to high-grade squamous intraepithelial lesions and then to squamous cervical carcinoma.
|
31336010 |
2019 |
|
Nasopharyngeal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
It was revealed that SALL4 expression was closely correlated with advanced T classification of NPC patients.
|
30907073 |
2019 |
|
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the function of SALL4 in cervical cancer remains unknown.
|
31336010 |
2019 |
|
Choriocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data indicate that aberrantly expressed SALL4 in human choriocarcinoma cells may promote cell proliferation via β-catenin/c-Myc pathway, indicating that SALL4 may be potential treatment targets of human choriocarcinoma.
|
28639477 |
2018 |
|
Lung Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here, we report that the expression of Sal-like protein 4 (SALL4), was significantly higher in EGFR mutated lung tumors than in non-tumor tissue.
|
29691367 |
2018 |
|
Mesothelioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, 175 well-characterized primary diffuse pleural mesotheliomas, including the epithelioid (n = 148), biphasic (n = 15), and sarcomatoid (n = 12) histotypes, were evaluated immunohistochemically for cancer stem cell markers (ALCAM, ALDH1, and SALL4) and PD-L1 expression.
|
28811252 |
2018 |
|
Osteoporosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study was aimed to explore the underlying mechanism of SALL4 in osteoporosis.
|
29241074 |
2018 |
|
Phocomelia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Human mutations in SALL4 cause Duane-radial ray, IVIC, and acro-renal-ocular syndromes with overlapping clinical presentations to thalidomide embryopathy, including phocomelia.
|
30190590 |
2018 |
|
Addictive Behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide.
|
29976840 |
2018 |
|
Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Prognostic Value of Cytokeratin and Sal-Like Protein 4 Expression in Hepatocellular Carcinoma and Intra-Hepatic Cholangiocarcinoma in Taiwan.
|
30588199 |
2018 |
|
Gastrointestinal Stromal Tumors
|
0.010 |
Biomarker
|
group |
BEFREE |
Our results showed that mRNA levels of B-lymphoma moloney murine leukaemia virus insertion region-1 (BMI1), kruppel-like factor 4 (KLF4), sal-like protein 4 (SALL4) and telomerase reverse transcriptase (TERT) were significantly unregulated in GISTs.
|
29486292 |
2018 |
|
Pancreatic Ductal Adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
SALL4 suppresses reactive oxygen species in pancreatic ductal adenocarcinoma phenotype via FoxM1/Prx III axis.
|
29958885 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, SALL4 might be a promising marker for PDAC treatment and targeting SALL4 would benefit anti-proliferative and anti-metastasis therapies.
|
29958885 |
2018 |
|
Atrial Fibrillation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Identification of TNFSF13, SPATC1L, SLC22A25 and SALL4 as novel susceptibility loci for atrial fibrillation by an exome‑wide association study.
|
28849223 |
2017 |
|
Congenital ocular coloboma (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Haploinsufficiency for SALL4 due to nonsense or frameshift mutations has been associated with acro-renal ocular syndrome that is characterized by eye defects including Duane anomaly and coloboma, in addition to radial ray malformations and renal abnormalities.
|
27661448 |
2017 |
|
Endocardial Cushion Defects
|
0.010 |
Biomarker
|
group |
BEFREE |
The presence of single atrioventricular canal instead of the atrial septal defect typical for Holt-Oram syndrome pointed us to rather suspect the SALL4 related diseases.
|
28807863 |
2017 |
|
Hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Indeed, increased SALL4 expression in hepatitis C virus-related HCCs correlated with demethylation of these CpG sites.
|
27797380 |
2017 |