SALL4, spalt like transcription factor 4, 57167

N. diseases: 245; N. variants: 17
Disease: leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia 		0.060 AlteredExpression disease BEFREE SALL4 is expressed constitutively in human leukemia cell lines and primary AML cells. 31552409 2019
CUI: C0023418
Disease: leukemia
leukemia 		0.060 Biomarker disease BEFREE These findings suggest that SALL4 plays an unfavorable role in ATRA-based regimes, highlighting an important aspect of leukemia therapy. 25737450 2015
CUI: C0023418
Disease: leukemia
leukemia 		0.060 Biomarker disease BEFREE Furthermore, targeting SALL4 with this approach could be an innovative approach in treating leukemia. 23287862 2013
CUI: C0023418
Disease: leukemia
leukemia 		0.060 Biomarker disease BEFREE We are the first to demonstrate a direct link between stem cell factor SALL4, SP and drug resistance in leukemia. 21526180 2011
CUI: C0023418
Disease: leukemia
leukemia 		0.060 AlteredExpression disease BEFREE Flow cytometry revealed that reduction of SALL4 expression in NB4 and other leukemia cell lines dramatically increased caspase-3, annexin V, and DNA fragmentation activity. 18487508 2008
CUI: C0023418
Disease: leukemia
leukemia 		0.060 AlteredExpression disease BEFREE Reducing SALL4 expression by siRNA in the HL-60 leukemia cell line also results in significant down-regulation of Bmi-1. 17557835 2007