BAD, BCL2 associated agonist of cell death, 572

N. diseases: 125; N. variants: 2
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.020 AlteredExpression disease BEFREE Diverse effects of vemurafenib-XL888 upon intratumoral HSP client protein expression were noted, with the expression of multiple proteins (including ERBB3 and BAD) modulated on therapy.<b>Conclusions:</b> XL888 in combination with vemurafenib has clinical activity in patients with advanced BRAF<sup>V600</sup>-mutant melanoma, with a tolerable side-effect profile. 29674508 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.020 Biomarker disease LHGDN Together, our data show that Bad and Bim are major B-RAF responsive proteins regulating apoptosis in melanoma cells. 18246127 2008