|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
KIAA1199 is a recently identified novel gene that is up-regulated in human cancer with poor survival.
|
24628760 |
2014 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
|
25350695 |
2014 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Recently, several reports have shown that the up-regulation of KIAA1199 is associated with cancer cell migration or invasion and a poor prognosis.
|
25051373 |
2014 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
KIAA1199 serves as a novel cell migration-promoting gene and plays a critical role in maintaining cancer mesenchymal status.
|
23990668 |
2013 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Plasma KIAA1199 RNA levels were significantly higher in patients with either cancer or adenoma (31/40) compared to neoplasia-free controls (6/20).
|
22276102 |
2012 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The regulatory mechanism controlling KIAA1199 expression in cancer remains to be characterized.
|
22970280 |
2012 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Functional studies and RNA-seq/ChIP-seq data revealed that inactivation of the protein CEMIP (which is translated by oncogene KIAA1199) by increasing H3K27me3 leads to decreased tumor cell growth and migration.
|
31846842 |
2020 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
CONCLUSIONS The miR-486-5p/KIAA1199/EMT axis might play a critical role in PTC invasion and metastasis and offers a potential therapeutic strategy for PTC.
|
31501407 |
2019 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Collectively, our study reveals that KIAA1199 promotes metastasis of colorectal cancer cells via microtubule destabilization regulated by a PP2A/stathmin pathway, and suggests that KIAA1199 may be a promising target for preventing metastasis in colorectal cancer.
|
30202098 |
2019 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
In summary, our data uncover KIAA1199 as a novel sorafenib-tolerant promoting gene that plays an indispensable role in maintaining sorafenib-resistant HCC cell metastasis.
|
30980868 |
2019 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Moreover, uptake of CEMIP<sup>+</sup> exosomes by brain endothelial and microglial cells induced endothelial cell branching and inflammation in the perivascular niche by upregulating the pro-inflammatory cytokines encoded by Ptgs2, Tnf and Ccl/Cxcl, known to promote brain vascular remodelling and metastasis.
|
31685984 |
2019 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
CEMIP was elevated in tumour tissues and exosomes from patients with brain metastasis and predicted brain metastasis progression and patient survival.
|
31685984 |
2019 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Here, we demonstrate that silencing of KIAA1199 results in reduced tumor metastasis in the orthotopic transplantation tumor model of colorectal cancer.
|
30202098 |
2019 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Knocking down of KIAA1199 expression in the mouse NSCLC xenograft model significantly suppressed tumor growth and augmented the efficacy of chemotherapy (n = 5; P < 0.05).
|
30478628 |
2019 |
|
Neoplasm Metastasis
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Our study proved that TUG1 promoted KIAA1199 expression to accelerate EMT and metastasis of CRC cell through inhibition of miR-600 expression.
|
29776371 |
2018 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Collectively, KIAA1199 plays a critical role in maintaining an aggressive phenotype of tumor cells, and suppression of KIAA1199-related motilities of tumor cells contributes to reduced tumor metastasis in colorectal cancer.
|
28213952 |
2017 |
|
Neoplasm Metastasis
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Firstly its mutation site was reported to cause hearing loss due to the folding change of protein structure, meanwhile the over-expression of CEMIP referred to dreadful invasion and uncontrolled proliferation of tumor with distant metastasis, dedifferentiation, and limited survival opportunity of patients.
|
28819426 |
2017 |
|
Neoplasm Metastasis
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
IHC results showed that 76 (49.67%) specimens had strong expression of KIAA1199 protein, with poor differentiation (P = 0.003), higher positive lymph node metastasis (P = 0.037), and higher tumor node metastasis stage (P = 0.016).
|
28901311 |
2017 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
IHC results showed that 76 (49.67%) specimens had strong expression of KIAA1199 protein, with poor differentiation (P = 0.003), higher positive lymph node metastasis (P = 0.037), and higher tumor node metastasis stage (P = 0.016).
|
28901311 |
2017 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Here, we intend to elaborate the clinical function and dysregulation of CEMIP under the tumorous circumstance since CEMIP plays an important role in cytokine pathway and its over-expression in tumors provide a novel target for individual therapy.
|
28819426 |
2017 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
In stage III only (n = 31) or in combined stage II plus stage III colon cancer cases (n = 73), 5-year overall survival was significantly better (p = 0.004 and p = 0.0003, respectively) among patients with low CEMIP expressing tumors than those with high CEMIP expressing tumors.
|
26437221 |
2015 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
KIAA1199 mRNA and protein was significantly overexpressed in breast tumor specimens and cell lines as compared with non-neoplastic breast tissues from large-scale microarray and studies of breast cancer cell lines and tumors.
|
24628760 |
2014 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Silencing of KIAA1199 in MDA-MB-435 cancer cells resulted in a mesenchymal-to-epithelial transition that reduced cell migratory ability in vitro (75% reduction; P < .001) and decreased metastasis in vivo (80% reduction; P < .001).
|
23990668 |
2013 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
KIAA1199 was selected for further analysis based on consistent up-regulation in neoplasia, previous studies and its interest as an uncharacterized gene.
|
22276102 |
2012 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis.
|
31685984 |
2019 |